Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Stanford University
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04930887CT.gov Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Trigeminal Autonomic Cephalalgia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Marcaine (this asset) | Stanford University | P2 | CCC · 53 |
| Immunoglobulin G, Anti-(Human Calcitonin Gene-Related Peptide Receptor) (Human Monoclonal Heavy Chain), Disulfide With Human Monoclonal Light Chain, Dimer | Beijing Tiantan Hospital | P2 | B |
| Capsaicin | The University of Texas Health Science Center, Houston | P1 | CC |
| AIR | The University of Texas Health Science Center, Houston | P1 | CC |
| Oxygen | The University of Texas Health Science Center, Houston | P1 | CC |
| Eptinezumab | Beijing Tiantan Hospital | Unk | D |
| Yangxue Qingnao Granules | Beijing Tiantan Hospital | Unk | D |
Other indications for Marcaine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Migraine Disorder | — | P4 | BBB · 74 |
| Neuralgia | — | P4 | BBB · 74 |
| Headache Disorder | — | P4 | BBB · 73 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- Immunoglobulin G, Anti-(Human Calcitonin Gene-Related Peptide Receptor) (Human Monoclonal Heavy Chain), Disulfide With Human Monoclonal Light Chain, DimerBeijing Tiantan HospitalB
- CapsaicinThe University of Texas Health Science Center, HoustonCC
- AIRThe University of Texas Health Science Center, HoustonCC
- OxygenThe University of Texas Health Science Center, HoustonCC
- EptinezumabBeijing Tiantan HospitalD
Citation
Floatz Terminal. Marcaine in Trigeminal Autonomic Cephalalgia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/1-butyl-26-pipecoloxylidide-monohydrochloride-trigeminal-autonomic-cephalalgia
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