(±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone
Bipolar Disorder
Explore 61 assets in Bipolar Disorder →Floatz Rating
BB68/100
Confidence
Indicative
Sponsor
Joshua Rosenblat
Modality
Small molecule
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
64High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07569198CT.gov Ketamine With Dialectical Behavioural Therapy (DBT) for Suicidality in Individuals With Treatment-Resistant Depression and Borderline Personality Disorder (KET-DBT) | — | Not Yet Recruiting | — | — | — |
NCT05625555CT.gov Predictors of Intravenous Ketamine Response in TRD | — | Active Not Recruiting | — | — | — |
NCT05786066CT.gov The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects | — | Recruiting | — | — | — |
NCT05339074CT.gov Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression | — | Completed | — | — | — |
NCT05004896CT.gov Ketamine for Treatment-Resistant Bipolar Disorder | — | Completed | — | — | — |
NCT05870501CT.gov Synaptic Imaging and Network Activity in Treatment Resistant Depression | — | Completed | — | — | — |
NCT05249309CT.gov Naturalistic Study of Ketamine in the Treatment of Depression | — | Unknown | — | — | — |
NCT04480918CT.gov University of Iowa Interventional Psychiatry Service Patient Registry | — | Recruiting | — | — | — |
NCT04399070CT.gov The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT) | — | Unknown | — | — | — |
NCT04209296CT.gov Chart Review of Patients Undergoing Ketamine Infusions | — | Completed | — | — | — |
Show 6 more trialsShow fewer
NCT05209217CT.gov Open Study of the Neurobiological Effects of Intranasal Ketamine in Children and Adults With Bipolar Disorder | — | Unknown | — | — | — |
NCT03367533CT.gov Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response, Pilot Trial | — | Completed | — | — | — |
NCT02882711CT.gov The UTHealth Ketamine Project | — | Terminated | — | — | — |
NCT01944293CT.gov Ketamine for Suicidality in Bipolar Depression | — | Completed | — | — | — |
NCT01833897CT.gov NMDA Antagonists in Bipolar Depression | — | Completed | — | — | — |
NCT00947791CT.gov Treatment Study of Bipolar Depression | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Bipolar Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone (this asset) | Joshua Rosenblat | Approved | BB · 68 |
| Asenapine | Dr. Stavroula Rakitzi | P4 | BBB |
| Quetiapine | First Affiliated Hospital of Zhejiang University | P4 | BBB |
| Lamotrigine | Johns Hopkins University | P4 | BBB |
| Escitalopram | First Affiliated Hospital of Zhejiang University | P4 | BBB |
| Paroxetine | Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital | P4 | BBB |
| Citalopram | University of Texas Southwestern Medical Center | P4 | BBB |
| Lithium, Elemental | University of Aarhus | P4 | BBB |
| Sertraline | University of Texas Southwestern Medical Center | P4 | BBB |
+42 more in the Bipolar Disorder cohort
Other indications for (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Chronic Pain Syndrome | — | P4 | BBB · 74 |
| Post-Traumatic Stress Disorder | — | P4 | BBB · 74 |
| Depressive Disorder | — | P4 | BBB · 74 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone in Bipolar Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/2-o-chlorophenyl-2-methylaminocyclohexanone-bipolar-disorder
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