2-PROPENOIC ACID, 3-(3,5-DICHLORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-2,3,4,9-TETRAHYDRO-3-METHYL-1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)-, (2E)-
Breast Cancer
Explore 849 assets in Breast Cancer →Floatz Rating
B58/100
Confidence
Indicative
Sponsor
Jiangsu Alphamab Biopharmaceuticals Co., Ltd
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
58Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07336771CT.gov JSKN016 in Combination With D-0502 for Locally Advanced or Metastatic HR-Positive, HER2-Negative Breast Cancer | — | Not Yet Recruiting | — | — | — |
NCT06954961CT.gov A Study to Evaluate D-0502 in Subjects With ER+ Her2- Locally Advanced or Metastatic Breast Cancer | — | Recruiting | — | — | — |
NCT03810625CT.gov Food Effect Study of D-0502 Tablet in Healthy Volunteers | — | Completed | — | — | — |
NCT03471663CT.gov A First-in-Human Study of D-0502 Alone and in Combination With Palbociclib in Women With Advanced or Metastatic ER-Positive and HER2-Negative Breast Cancer | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Breast Cancer
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| 2-PROPENOIC ACID, 3-(3,5-DICHLORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-2,3,4,9-TETRAHYDRO-3-METHYL-1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)-, (2E)- (this asset) | Jiangsu Alphamab Biopharmaceuticals Co., Ltd | P3 | B · 58 |
| Darolutamide | Vandana Abramson | P2 | BBB |
| Pertuzumab | SWOG Cancer Research Network | P4 | BB |
| Palbociclib | Hoffmann-La Roche | P4 | BB |
| Trastuzumab Duocarmazine | Byondis B.V. | P3 | BB |
| Goserelin | TerSera Therapeutics LLC | P4 | BB |
| Ribociclib | National Cancer Institute (NCI) | P4 | BB |
| Oxaliplatin | Beijing Biostar Pharmaceuticals Co., Ltd. | P4 | BB |
| Eribulin Monomethanesulfonate | Henan Cancer Hospital | P4 | BB |
+42 more in the Breast Cancer cohort
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. 2-PROPENOIC ACID, 3-(3,5-DICHLORO-4-((1R,3R)-2-(2-FLUORO-2-METHYLPROPYL)-2,3,4,9-TETRAHYDRO-3-METHYL-1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)-, (2E)- in Breast Cancer. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/2-propenoic-acid-3-35-dichloro-4-1r3r-2-2-fluoro-2-methylpropyl-2349-tetrahydro-3-methyl-1h-pyrido34-bindol-1-ylphenyl-2e-breast-cancer
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