Floatz Rating
B56/100
Confidence
Indicative
Sponsor
Fundacion Clinic per a la Recerca Biomédica
Modality
Small molecule
Development Phase
Phase 2/3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
43Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01456286CT.gov Randomized Controlled Trial to Assess the Effects of Sapropterin on Hepatic and Systemic Hemodynamics in Patients With Liver Cirrhosis and Portal Hypertension | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Portal Hypertension
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN (this asset) | Fundacion Clinic per a la Recerca Biomédica | P2/3 | B · 56 |
| Carvedilol | West China Hospital | P4 | BBB |
| Simvastatin | Kafrelsheikh University | P4 | BBB |
| Apsolol | West China Hospital | P4 | BBB |
| Apixaban | Asian Institute Of Medical Sciences | P4 | BB |
| Lactulose | University of Michigan | P4 | BB |
| Warfarin | Northern Jiangsu People's Hospital | P4 | BB |
| Aspirin | Northern Jiangsu People's Hospital | P4 | BB |
| Dipyridamole | Northern Jiangsu People's Hospital | P4 | BB |
+42 more in the Portal Hypertension cohort
Other indications for (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Lesch-Nyhan Syndrome | — | P2/3 | B · 56 |
| Phenylketonuria | — | P2 | CCC · 53 |
| Cirrhosis Of Liver | — | P2/3 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. (6S)-L-ERYTHRO-TETRAHYDROBIOPTERIN in Portal Hypertension. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/6s-l-erythro-tetrahydrobiopterin-portal-hypertension
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