Acalabrutinib
Chronic Graft Versus Host Disease
Explore 3 assets in Chronic Graft Versus Host Disease →Floatz Rating
B57/100
Confidence
Indicative
Sponsor
Polish Lymphoma Research Group
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04716075CT.gov Acalabrutinib in CLL and MCL Patients Subjected to Allogeneic Hematopoietic Stem Cell Transplantation (alloSCT) | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Chronic Graft Versus Host Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Acalabrutinib (this asset) | Polish Lymphoma Research Group | P2 | B · 57 |
| Ibrutinib | Janssen Research & Development, LLC | P3 | B |
| Vimseltinib | Deciphera Pharmaceuticals, LLC | P2 | CCC |
| 5-ala | St. Olavs Hospital | P1/2 | CCC |
| trx103 | Tr1X, Inc. | P1 | NR |
Other indications for Acalabrutinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| B-Cell Chronic Lymphocytic Leukemia | — | P4 | BBB · 75 |
| Follicular Lymphoma | — | P2 | BB · 70 |
| Diffuse Large B-Cell Lymphoma | — | P3 | BB · 65 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Acalabrutinib in Chronic Graft Versus Host Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/acalabrutinib-chronic-graft-versus-host-disease
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