Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Yale University
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06996652CT.gov An Exploratory Study of the Potential for Rational Immune System Manipulation to Prevent Emergence of Synucleinopathy Manifestations in Persons With REM Sleep Behavior Disorder (RBD) | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · REM Sleep Behavior Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Adalimumab (this asset) | Yale University | P2 | CCC · 53 |
| Ioflupane | Weill Medical College of Cornell University | P4 | BBB |
| 3-IODOBENZYLGUANIDINE (123I) | Mayo Clinic | P4 | BB |
| .Gamma.-Hydroxybutyrate Sodium Salt | Stanford University | P4 | BB |
| Clonazepam | Seoul National University Hospital | P2 | B |
| Idebenone | Second Affiliated Hospital, School of Medicine, Zhejiang University | P2/3 | B |
| Rasagiline | Second Affiliated Hospital, School of Medicine, Zhejiang University | P2/3 | B |
| Carvedilol | Cedars-Sinai Medical Center | P2 | CCC |
| Melatonin | Seoul National University Hospital | P2 | CCC |
+9 more in the REM Sleep Behavior Disorder cohort
Other indications for Adalimumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Obstructive Sleep Apnea Syndrome | — | P4 | BB · 69 |
| Psoriasis | — | P4 | BB · 68 |
| Sciatica | — | P2 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Adalimumab in REM Sleep Behavior Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/adalimumab-rem-sleep-behavior-disorder
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