Alpha/Beta T Cell-Depleted Hematopoietic Stem Cells
Juvenile Myelomonocytic Leukemia
Explore 27 assets in Juvenile Myelomonocytic Leukemia →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Masonic Cancer Center, University of Minnesota
Modality
Cell therapy
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05735717CT.gov MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Juvenile Myelomonocytic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Alpha/Beta T Cell-Depleted Hematopoietic Stem Cells (this asset) | Masonic Cancer Center, University of Minnesota | P2 | CCC · 53 |
| Cyclophosphamide | Masonic Cancer Center, University of Minnesota | P4 | BBB |
| Busulfanum | Masonic Cancer Center, University of Minnesota | P4 | BBB |
| Thiotepa | St. Jude Children's Research Hospital | P3 | BBB |
| Fludarabine | Children's Oncology Group | P3 | BB |
| Cyclosporin A | Case Comprehensive Cancer Center | P3 | BB |
| Nivestim | Masonic Cancer Center, University of Minnesota | P3 | BB |
| Tacrolimus | Masonic Cancer Center, University of Minnesota | P2 | BB |
| Rituximab | Masonic Cancer Center, University of Minnesota | P3 | BB |
+36 more in the Juvenile Myelomonocytic Leukemia cohort
Other indications for Alpha/Beta T Cell-Depleted Hematopoietic Stem Cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Li-Fraumeni Syndrome | — | P2 | CCC · 53 |
| B-Lymphoblastic Leukemia/Lymphoma With IAMP21 | — | P2 | CCC · 53 |
| Central Nervous System Leukemia | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Alpha/Beta T Cell-Depleted Hematopoietic Stem Cells in Juvenile Myelomonocytic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/alphabeta-t-cell-depleted-hematopoietic-stem-cells-juvenile-myelomonocytic-leukemia
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