Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00089362CT.gov Alvespimycin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Adenoid Cystic Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Alvespimycin (this asset) | National Cancer Institute (NCI) | P1 | CC · 47 |
| Cetuximab | Fox Chase Cancer Center | P1/2 | B |
| Irinotecan | National Cancer Institute (NCI) | P1/2 | B |
| Vipivotide Tetraxetan | Maria Sklodowska-Curie National Research Institute of Oncology | P2 | CCC |
| Nivolumab | Instituto do Cancer do Estado de São Paulo | P2 | CCC |
| Ipilimumab | National Cancer Institute (NCI) | P2 | CCC |
| Pembrolizumab | Seagen, a wholly owned subsidiary of Pfizer | P1/2 | CCC |
| Everolimus | Emory University | P1 | CCC |
| Recombinant Interleukin-12 | National Cancer Institute (NCI) | P1 | CC |
+20 more in the Adenoid Cystic Carcinoma cohort
Other indications for Alvespimycin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cancer Of Unknown Primary Site | — | P1 | CCC · 52 |
| Basal Cell Carcinoma | — | P1 | CC · 47 |
| Salivary Gland Adenoid Cystic Carcinoma | — | P1 | CC · 47 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Alvespimycin in Adenoid Cystic Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/alvespimycin-adenoid-cystic-carcinoma
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