Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
University of Pennsylvania
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05140148CT.gov Promoting Recovery After STroke With Amantadine | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hemorrhagic Stroke
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Amantadine (this asset) | University of Pennsylvania | P2 | CCC · 53 |
| Melatonin | Hospital San Carlos, Madrid | P4 | BB |
| Cerebrolysin | Cardinal Stefan Wyszynski University | P4 | BB |
| Esmolol | Cristália Produtos Químicos Farmacêuticos Ltda. | P4 | BB |
| Atorvastatin | Duan Chuanzhi | P4 | BB |
| Xingnaojing | Peking University Third Hospital | P4 | BB |
| Shuxuetong | Peking University Third Hospital | P4 | BB |
| Compound Solution Of Sodium Chloride | University Hospital Heidelberg | P2 | B |
| Tranexamic Acid | Kwong Wah Hospital | P3 | B |
+17 more in the Hemorrhagic Stroke cohort
Other indications for Amantadine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Drug-Induced Dyskinesia | — | P3 | BBB · 72 |
| Parkinson Disease | — | P4 | BBB · 72 |
| Traumatic Brain Injury | — | P4 | BB · 70 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Amantadine in Hemorrhagic Stroke. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/amantadine-hemorrhagic-stroke
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