Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Centre Hospitalier Universitaire de Nice
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04063540CT.gov Acid-Sensing Ion Channel and Migraine Disease Proof of Concept Study on the Efficacy of Amiloride in the Prophylaxis of Migraine Aura | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Migraine With Aura
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Amiloride (this asset) | Centre Hospitalier Universitaire de Nice | P2 | CCC · 53 |
| Topiramate | Tongji Hospital | P4 | BBB |
| DHE | Satsuma Pharmaceuticals, Inc. | P3 | BB |
| Apsolol | Norwegian University of Science and Technology | P3 | BB |
| Rimegepant | University of South Florida | P4 | BB |
| Dfn-11 (Sumatriptan Injection) | University of Aarhus | P3 | BB |
| Almotriptan | Messoud Ashina, MD | P4 | BB |
| Metoclopramide | Assistance Publique - Hôpitaux de Paris | P4 | BB |
| Tonabersat | Minster Research Ltd | P2 | B |
+40 more in the Migraine With Aura cohort
Other indications for Amiloride
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Nephrotic Syndrome | — | P3 | B · 60 |
| Bipolar Disorder | — | P4 | B · 59 |
| Cystic Fibrosis | — | P2 | B · 58 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Amiloride in Migraine With Aura. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/amiloride-migraine-with-aura
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