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Amrubicin

Small Cell Lung Carcinoma

Explore 277 assets in Small Cell Lung Carcinoma
Floatz Rating
B59/100
Confidence
Indicative
v0.2
Sponsor
AbbVie
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
56High confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
A Study to Evaluate Adverse Events and Change in Disease Activity of Intravenous ABBV-706 Versus Standard of Care in Adult Participants With Relapsed/Refractory Small Cell Lung Cancer
Not Yet Recruiting
A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)
Recruiting
Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer
Recruiting
A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer
Recruiting
Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer
Active Not Recruiting
Pembrolizumab Plus Amurubicin in Patients With Refractory Small-cell Lung Cancer
Unknown
A Phase 2 Study Comparing TAS-102 Versus Topotecan or Amrubicin to Treat Small Cell Lung Cancer Following Platinum-Based Chemotherapy
Terminated

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · Small Cell Lung Carcinoma

AssetSponsorPhaseRating
Amrubicin (this asset)AbbVieP3B · 59
BenmelstobartYayi HeP4A
BerzosertibNational Cancer Institute (NCI)P2BBB
Anti-Pd-L1 Monoclonal Antibody Shr-1316Suzhou Suncadia Biopharmaceuticals Co., Ltd.P3BBB
Cis-Diamminedichloroplatinum IiNational Cancer Institute (NCI)P4BBB
EtoposideSichuan UniversityP4BBB
VeliparibCentral European Society for Anticancer Drug ResearchP2BB
CarboplatinUniversity of Maryland, BaltimoreP4BB
L-Kappa-H-Gamma1 (Knob) Chain Anti-Dll3 (1-705) [L-Kappa Anti-Dll3 (1-214) [V-Kappa (Homo Sapiens Igkv1-17*03 (94.9%) -Igkj2*01 (100%), Cdr-Imgt [6.3.9] (27-32.50-52.89-97)) (1-107) -Homo Sapiens Igkc*01 (100%), Km3 A45.1 (153), V101 (191) (108'-214')] -38-Mer (Ggggse Gkssgsgses Kstegkssgs Gseskstggggs) Linker (215-252) -H-Gamma-1 Heavy Chain Anti-Dll3 (253-705) [Vh (Homo Sapiens Ighv1-46*01 (92.9%) -(Ighd) -Ighj6*01 (94.7%), Cdr-Imgt [8.8.17] (278-285.303-310.349-365)) (253-376)-Homo Sapiens Ighg1*03, G1M3, Ng1M1, Ch1 R120, Ch3 E12, M14, G1V14 Ch2 A1.3, A1.2, G1V32 Ch3 W22 (Knob) (Ch1 R120 (473) (377-474), Hinge 1-15 (475-489), Ch2 L1.3>A (493), L1.2>A (494) (490-599), Ch3 E12 (615), M14 (617), T22>W (625) (600-704), Chs K2>Del (705)) (377-705)]]; L-Lambda6-H-Gamma1 (Hole) Chain Anti-Cd3E (1-707) [L-Lambda6 Anti-Cd3 (1'-215') [V-Lambda Musmus/Homsap (Mus Musculus Iglv1*01 (82.3%) -Iglj1*01 (100%)/Homo Sapiens Iglv7-46*01 (76.8%) -Iglj3*02 (100%), Cdr-Imgt [9.3.9] (26'-34'.52'-54'.91'-99')) (1'-109') -Homo Sapiens Iglc6*01 (100%) (110'-215')] -38-Mer (Ggggse Gkssgsgses Kstegkssgsgseskstggggs) Linker (216'-253') -H-Gamma-1 Anti-Cd3E (254'-707') [Vh Musmus/Homsap (Mus Musculus Ighv10-1*02 (92.9%) -(Ighd) -Ighj3*01 (100%)/Homo Sapiens Ighv3-73*01 (87.0%) -(Ighd) -Ighj6*01 (81.8%) T123>L (373'), S128>A (378'), Cdr-Imgt [8.10.16] (279'-286'.304'-313'.352'-367')) (254'-378')-Homo Sapiens Ighg1*03, G1M3, Ng1M1, Ch1 R120, Ch3 E12, M14, G1V14 Ch2 A1.3, A1.2, G1V33 Ch3 S22, A24, V86 (Hole), G1V83 Ch3 R115, F116 (Ch1 R120 (475') (379'-476'), Hinge 1-15 (477'-491'), Ch2 L1.3>A (495'), L1.2>A (496') (492'-601'), Ch3 E12 (617'), M14 (619'), T22>S (627'), L24>A (629'), Y86>V (686'), H115>R (696'), Y116>F (697') (602'-706'), Chs K2>Del (707')) (379'-707')]]; Dimer (485-487':488-490')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Cho-K1, Glycoform AlfaBoehringer IngelheimP3BB

+42 more in the Small Cell Lung Carcinoma cohort

Other indications for Amrubicin

IndicationSponsorPhaseRating
Lung CancerP3BB · 66
Breast CancerP2B · 58
Plasma Cell MyelomaP1/2CC · 42

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Amrubicin in Small Cell Lung Carcinoma. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/amrubicin-small-cell-lung-carcinoma

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