Anti-Pd-L1 Monoclonal Antibody Ck-301
Richter Transformation
Explore 57 assets in Richter Transformation →Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
TG Therapeutics, Inc.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03778073CT.gov Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma | — | Terminated | — | — | — |
NCT02535286CT.gov Study of Immunotherapy in Combination With Ublituximab and Umbralisib in Patients With Relapsed-refractory CLL or Richter's Transformation | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Richter Transformation
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Anti-Pd-L1 Monoclonal Antibody Ck-301 (this asset) | TG Therapeutics, Inc. | P1 | CC · 41 |
| Obinutuzumab | Christine Ryan | P2 | BB |
| Venetoclax | Northwestern University | P2 | BB |
| Ibrutinib | City of Hope Medical Center | P2 | BB |
| Prednisone | SWOG Cancer Research Network | P3 | BB |
| Cyclophosphamide | SWOG Cancer Research Network | P3 | BB |
| Rituximab | SWOG Cancer Research Network | P3 | BB |
| Pirtobrutinib | SWOG Cancer Research Network | P3 | BB |
| Adriamycin | SWOG Cancer Research Network | P3 | BB |
+42 more in the Richter Transformation cohort
Other indications for Anti-Pd-L1 Monoclonal Antibody Ck-301
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Skin Squamous Cell Carcinoma | — | P4 | B · 58 |
| Skin Cancer | — | P4 | CCC · 54 |
| Non-Small Cell Lung Carcinoma | — | P3 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Anti-Pd-L1 Monoclonal Antibody Ck-301 in Richter Transformation. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/anti-pd-l1-monoclonal-antibody-ck-301-richter-transformation
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