Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Ascentage Pharma Group Inc.
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04496349CT.gov A Study Evaluating APG-115 as a Single Agent or in Combination With APG-2575 in Subjects With R/R T-PLL and NHL | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · T-Cell Prolymphocytic Leukemia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Apg 115 (this asset) | Ascentage Pharma Group Inc. | P2 | CCC · 53 |
| Cytarabine | M.D. Anderson Cancer Center | P2 | BB |
| Cyclophosphamide | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | P2 | BB |
| Fludarabine | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | P3 | BB |
| Cyclosporin A | Fred Hutchinson Cancer Center | P3 | BB |
| Etoposide | Fred Hutchinson Cancer Center | P2 | BB |
| Melphalan | Fred Hutchinson Cancer Center | P2 | BB |
| Sirolimus | Fred Hutchinson Cancer Center | P3 | BB |
| Camustine | Fred Hutchinson Cancer Center | P2 | BB |
+20 more in the T-Cell Prolymphocytic Leukemia cohort
Other indications for Apg 115
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Hodgkin Lymphoma | — | P2 | CCC · 53 |
| Cancer | — | P1/2 | CCC · 48 |
| Acute Myeloid Leukemia | — | P1/2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- CytarabineM.D. Anderson Cancer CenterBB
- CyclophosphamideUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyBB
- FludarabineUnion Hospital, Tongji Medical College, Huazhong University of Science and TechnologyBB
- Cyclosporin AFred Hutchinson Cancer CenterBB
- EtoposideFred Hutchinson Cancer CenterBB
Citation
Floatz Terminal. Apg 115 in T-Cell Prolymphocytic Leukemia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/apg-115-t-cell-prolymphocytic-leukemia
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