Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tcm-Enriched T Cells
Splenic Marginal Zone Lymphoma
Explore 32 assets in Splenic Marginal Zone Lymphoma →Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
Cell therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01815749CT.gov Genetically Modified T-cell Infusion Following Peripheral Blood Stem Cell Transplant in Treating Patients With Recurrent or High-Risk Non-Hodgkin Lymphoma | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Splenic Marginal Zone Lymphoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tcm-Enriched T Cells (this asset) | City of Hope Medical Center | P1 | CC · 41 |
| Etoposide | Fred Hutchinson Cancer Center | P2 | BB |
| Vincristine Sulfate | SWOG Cancer Research Network | P3 | BB |
| Dexasone | Izidore Lossos, MD | P2 | BB |
| Cyclosporin A | National Cancer Institute (NCI) | P2 | BB |
| Cediranib | National Cancer Institute (NCI) | P2 | BB |
| Zanubrutinib | SWOG Cancer Research Network | P3 | BB |
| Rituximab | City of Hope Medical Center | P3 | BB |
| Adriamycin | SWOG Cancer Research Network | P3 | BB |
+42 more in the Splenic Marginal Zone Lymphoma cohort
Other indications for Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tcm-Enriched T Cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Primary Cutaneous B-Cell Lymphoma | — | P1 | CC · 43 |
| Grade III Lymphomatoid Granulomatosis | — | P1 | CC · 43 |
| Intraocular Lymphoma | — | P1 | CC · 43 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Autologous Cd19Car-Cd28-Cd3Zeta-Egfrt-Expressing Tcm-Enriched T Cells in Splenic Marginal Zone Lymphoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/autologous-cd19car-cd28-cd3zeta-egfrt-expressing-tcm-enriched-t-cells-splenic-marginal-zone-lymphoma
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