Autologous Peripheral Blood Mononuclear Cell (Pbmc)-Derived T Lymphocytes Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector Encodinga Chimeric Antigen Receptor (Car) Targeting Two Epitopes Of The Human B Cell Maturation Antigen (Bcma) Under The Control Of A Human Elongation Factor 1 Alpha (Ef1.Alpha.) Promoter The Coding Sequence Comprises A Human Cd8 Alpha Signal Peptide (Cd8.Alpha. Sp), A Bcma Targeting Domain Consisting Of Two Variable Heavy Chain-Only Antibodies (Vhh1 And Vhh2) Targeting Two Distinct Bcma Epitopes, A Human Cd8 Alpha Hinge And Transmembrane Domain (Cd8.Alpha. Hinge + Tm), A Human Cd137 Cytoplasmic Domain (4-1Bb) And A Human Cd3 Zeta Cytoplasmic Domain (Cd3.Zeta.). The Vector Genome Contains A Chimeric Rous Sarcoma Virus (Rsv)/Truncated 5'Ltr And A Self-Inactivating 3'Ltr-Sin (.Delta.-U3)
Extramedullary Plasmacytoma
Explore 1 assets in Extramedullary Plasmacytoma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Peter MacCallum Cancer Centre, Australia
Modality
Cell therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05666700CT.gov CAR-T Cell Therapy in RelApsed/Refractory Myeloma With ExtrameduLlary Disease - an in Vivo Imaging and Molecular Monitoring Study | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Extramedullary Plasmacytoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Autologous Peripheral Blood Mononuclear Cell (Pbmc)-Derived T Lymphocytes Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector Encodinga Chimeric Antigen Receptor (Car) Targeting Two Epitopes Of The Human B Cell Maturation Antigen (Bcma) Under The Control Of A Human Elongation Factor 1 Alpha (Ef1.Alpha.) Promoter The Coding Sequence Comprises A Human Cd8 Alpha Signal Peptide (Cd8.Alpha. Sp), A Bcma Targeting Domain Consisting Of Two Variable Heavy Chain-Only Antibodies (Vhh1 And Vhh2) Targeting Two Distinct Bcma Epitopes, A Human Cd8 Alpha Hinge And Transmembrane Domain (Cd8.Alpha. Hinge + Tm), A Human Cd137 Cytoplasmic Domain (4-1Bb) And A Human Cd3 Zeta Cytoplasmic Domain (Cd3.Zeta.). The Vector Genome Contains A Chimeric Rous Sarcoma Virus (Rsv)/Truncated 5'Ltr And A Self-Inactivating 3'Ltr-Sin (.Delta.-U3) (this asset) | Peter MacCallum Cancer Centre, Australia | P1 | CC · 43 |
Other indications for Autologous Peripheral Blood Mononuclear Cell (Pbmc)-Derived T Lymphocytes Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector Encodinga Chimeric Antigen Receptor (Car) Targeting Two Epitopes Of The Human B Cell Maturation Antigen (Bcma) Under The Control Of A Human Elongation Factor 1 Alpha (Ef1.Alpha.) Promoter The Coding Sequence Comprises A Human Cd8 Alpha Signal Peptide (Cd8.Alpha. Sp), A Bcma Targeting Domain Consisting Of Two Variable Heavy Chain-Only Antibodies (Vhh1 And Vhh2) Targeting Two Distinct Bcma Epitopes, A Human Cd8 Alpha Hinge And Transmembrane Domain (Cd8.Alpha. Hinge + Tm), A Human Cd137 Cytoplasmic Domain (4-1Bb) And A Human Cd3 Zeta Cytoplasmic Domain (Cd3.Zeta.). The Vector Genome Contains A Chimeric Rous Sarcoma Virus (Rsv)/Truncated 5'Ltr And A Self-Inactivating 3'Ltr-Sin (.Delta.-U3)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Plasma Cell Myeloma | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Citation
Floatz Terminal. Autologous Peripheral Blood Mononuclear Cell (Pbmc)-Derived T Lymphocytes Transduced Ex Vivo With A Non-Replicating, Self-Inactivating (Sin) Lentiviral Vector Encodinga Chimeric Antigen Receptor (Car) Targeting Two Epitopes Of The Human B Cell Maturation Antigen (Bcma) Under The Control Of A Human Elongation Factor 1 Alpha (Ef1.Alpha.) Promoter The Coding Sequence Comprises A Human Cd8 Alpha Signal Peptide (Cd8.Alpha. Sp), A Bcma Targeting Domain Consisting Of Two Variable Heavy Chain-Only Antibodies (Vhh1 And Vhh2) Targeting Two Distinct Bcma Epitopes, A Human Cd8 Alpha Hinge And Transmembrane Domain (Cd8.Alpha. Hinge + Tm), A Human Cd137 Cytoplasmic Domain (4-1Bb) And A Human Cd3 Zeta Cytoplasmic Domain (Cd3.Zeta.). The Vector Genome Contains A Chimeric Rous Sarcoma Virus (Rsv)/Truncated 5'Ltr And A Self-Inactivating 3'Ltr-Sin (.Delta.-U3) in Extramedullary Plasmacytoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/autologous-peripheral-blood-mononuclear-cell-pbmc-derived-t-lymphocytes-transduced-ex-vivo-with-a-non-replicating-self-inactivating-sin-lentiviral-vector-encodinga-chimeric-antigen-receptor-car-targeting-two-epitopes-of-the-human-b-cell-maturation-antigen-bcma-under-the-control-of-a-human-elongation-factor-1-alpha-ef1alpha-promoter-the-coding-sequence-comprises-a-human-cd8-alpha-signal-peptide-cd8alpha-sp-a-bcma-targeting-domain-consisting-of-two-variable-heavy-chain-only-antibodies-vhh1-and-vhh2-targeting-two-distinct-bcma-epitopes-a-human-cd8-alpha-hinge-and-transmembrane-domain-cd8alpha-hinge-tm-a-human-cd137-cytoplasmic-domain-4-1bb-and-a-human-cd3-zeta-cytoplasmic-domain-cd3zeta-the-vector-genome-contains-a-chimeric-rous-sarcoma-virus-rsvtruncated-5ltr-and-a-self-inactivating-3ltr-sin-delta-u3-extramedullary-plasmacytoma
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