Autologous Total Tumor Mrna Loaded Dotap Liposome Vaccine
Soft Tissue Sarcoma
Explore 102 assets in Soft Tissue Sarcoma →Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
University of Florida
Modality
vaccine
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05264974CT.gov Novel RNA-lipid Particle (RNA-LP) Vaccine for Anti-PD-1 Antibody Therapy Sensitization | — | Suspended | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Soft Tissue Sarcoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Autologous Total Tumor Mrna Loaded Dotap Liposome Vaccine (this asset) | University of Florida | P1 | CC · 41 |
| Palbociclib | Brown University | P2 | BB |
| Nivestim | University of California, Irvine | P3 | BB |
| Cyclophosphamide | St. Jude Children's Research Hospital | P2 | BB |
| Adriamycin | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | P3 | BB |
| Dacarbazine | Institut Bergonié | P3 | BB |
| Irinotecan | GI Innovation, Inc. | P1/2 | BB |
| Olaparib | OHSU Knight Cancer Institute | P2 | BB |
| Tislelizumab | Gustave Roussy, Cancer Campus, Grand Paris | P3 | BB |
+42 more in the Soft Tissue Sarcoma cohort
Other indications for Autologous Total Tumor Mrna Loaded Dotap Liposome Vaccine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Melanoma | — | P1 | C · 37 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Autologous Total Tumor Mrna Loaded Dotap Liposome Vaccine in Soft Tissue Sarcoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/autologous-total-tumor-mrna-loaded-dotap-liposome-vaccine-soft-tissue-sarcoma
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