Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
G1 Therapeutics, Inc.
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04887831CT.gov Trilaciclib, a CDK 4/6 Inhibitor, in Patients With Advanced/Metastatic Bladder Cancer Receiving Chemotherapy Then Avelumab | — | Terminated | — | — | — |
NCT04848519CT.gov Immune Checkpoint Inhibitors With or Without Propranolol Hydrochloride In Patients With Urothelial Carcinoma | — | Active Not Recruiting | — | — | — |
NCT04902040CT.gov Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Urinary Bladder Cancer
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Avelumab (this asset) | G1 Therapeutics, Inc. | P2 | CCC · 53 |
| Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4) | Fred Hutchinson Cancer Center | P2 | BB |
| Atezolizumab | National Cancer Institute (NCI) | P2 | BB |
| Carboplatin | Iambic Therapeutics, Inc | P2 | BB |
| Pembrolizumab | Fred Hutchinson Cancer Center | P2 | BB |
| Trastuzumab | Iambic Therapeutics, Inc | P2 | BB |
| Nivolumab | M.D. Anderson Cancer Center | P2 | B |
| Adriamycin | M.D. Anderson Cancer Center | P2 | B |
| Cabozantinib | National Cancer Institute (NCI) | P2 | B |
+37 more in the Urinary Bladder Cancer cohort
Other indications for Avelumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Urothelial Carcinoma | — | P3 | B · 58 |
| Non-Small Cell Lung Carcinoma | — | P3 | B · 58 |
| Bladder Transitional Cell Carcinoma | — | P3 | B · 57 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- Enfortumab Vedotin (Fully Human Monoclonal Antibody Conjugated To A Cytotoxic Agent Monomethyl Auristatin E (Mmae) Targeting Nectin-4)Fred Hutchinson Cancer CenterBB
- AtezolizumabNational Cancer Institute (NCI)BB
- CarboplatinIambic Therapeutics, IncBB
- PembrolizumabFred Hutchinson Cancer CenterBB
- TrastuzumabIambic Therapeutics, IncBB
Citation
Floatz Terminal. Avelumab in Urinary Bladder Cancer. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/avelumab-urinary-bladder-cancer
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