Axicabtagene Ciloleucel
High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit
Explore 34 assets in High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
Cell therapy
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07042438CT.gov Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Axicabtagene Ciloleucel (this asset) | City of Hope Medical Center | P2 | CCC · 53 |
| Rituximab | Yazeed Sawalha | P2 | B |
| Cyclophosphamide | Mayo Clinic | P2 | B |
| Prednisone | National Cancer Institute (NCI) | P2 | B |
| Dexasone | National Cancer Institute (NCI) | P2 | B |
| Ibrutinib | National Cancer Institute (NCI) | P2 | B |
| Venetoclax | National Cancer Institute (NCI) | P2 | B |
| Etoposide | David Bond, MD | P2 | B |
| (+)-Vincristine | Patrick C. Johnson, MD | P2 | B |
+32 more in the High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit cohort
Other indications for Axicabtagene Ciloleucel
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Diffuse Large B-Cell Lymphoma | — | P4 | BBB · 75 |
| Primary Mediastinal Large B-Cell Lymphoma | — | P2 | BB · 71 |
| High Grade B-Cell Lymphoma | — | P2 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Axicabtagene Ciloleucel in High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/axicabtagene-ciloleucel-high-grade-b-cell-lymphoma-double-hittriple-hit
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