Azacitidine
Myelodysplastic Syndrome With Excess Blasts-1
Explore 12 assets in Myelodysplastic Syndrome With Excess Blasts-1 →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01522976CT.gov Azacitidine With or Without Lenalidomide or Vorinostat in Treating Patients With Higher-Risk Myelodysplastic Syndromes or Chronic Myelomonocytic Leukemia | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Myelodysplastic Syndrome With Excess Blasts-1
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Azacitidine (this asset) | National Cancer Institute (NCI) | P2 | CCC · 53 |
| Cyclosporin A | Singapore Eye Research Institute | P4 | B |
| Cyclophosphamide | Masonic Cancer Center, University of Minnesota | P2 | B |
| Thiotepa | Fred Hutchinson Cancer Center | P2 | B |
| Fludarabine | Masonic Cancer Center, University of Minnesota | P2 | B |
| Busulfanum | Fred Hutchinson Cancer Center | P2 | B |
| Tacrolimus | Fred Hutchinson Cancer Center | P2 | B |
| Methotrexate | Fred Hutchinson Cancer Center | P2 | B |
| Abatacept Recombinant | Boston Children's Hospital | P2 | B |
+5 more in the Myelodysplastic Syndrome With Excess Blasts-1 cohort
Other indications for Azacitidine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Acute Myeloid Leukemia With Abnormal Bone Marrow Eosinophils Inv(16)(P13q22) Or T(16;16)(P13;Q22) | — | P2 | BBB · 73 |
| Acute Erythroid Leukemia | — | P2 | BB · 71 |
| Acute Myeloid Leukemia With 11q23 Abnormalities | — | P2 | BB · 71 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Azacitidine in Myelodysplastic Syndrome With Excess Blasts-1. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/azacitidine-myelodysplastic-syndrome-with-excess-blasts-1
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