Floatz Rating
C39/100
Confidence
Indicative
Sponsor
St. Jude Children's Research Hospital
Modality
Cell therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04897321CT.gov B7-H3-Specific Chimeric Antigen Receptor Autologous T-Cell Therapy for Pediatric Patients With Solid Tumors (3CAR) | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Rhabdomyosarcoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| b7-h3 car t cells (this asset) | St. Jude Children's Research Hospital | P1 | C · 39 |
| Ipilimumab | Children's National Research Institute | P2 | BB |
| Irinotecan | Milton S. Hershey Medical Center | P2 | BB |
| Calcium Phosphate | Children's Oncology Group | P3 | BB |
| Cixutumumab | National Cancer Institute (NCI) | P2 | B |
| Adriamycin | Children's National Research Institute | P2 | B |
| Oxaliplatin | National Cancer Institute (NCI) | P2 | B |
| Cyclophosphamide | National Cancer Institute (NCI) | P3 | B |
| Vinorelbine Ditartrate | Children's Oncology Group | P3 | B |
+42 more in the Rhabdomyosarcoma cohort
Other indications for b7-h3 car t cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Wilms Tumor | — | P1 | CC · 43 |
| Adrenal Cortex Carcinoma | — | P1 | CC · 43 |
| Desmoplastic Small Round Cell Tumor | — | P1 | CC · 43 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. b7-h3 car t cells in Rhabdomyosarcoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/b7-h3-car-t-cells-rhabdomyosarcoma
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