Floatz Rating
B60/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
monoclonal_antibody
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
45Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07595874CT.gov Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3 | — | Recruiting | — | — | — |
NCT06780787CT.gov FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery | — | Recruiting | — | — | — |
NCT06575725CT.gov Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer | — | Withdrawn | — | — | — |
NCT05627635CT.gov FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Rectum Adenocarcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Balstilimab (this asset) | City of Hope Medical Center | P2 | B · 60 |
| Fluorouracilum | Merck Sharp & Dohme LLC | P3 | BBB |
| Irinotecan | Sixth Affiliated Hospital, Sun Yat-sen University | P3 | BBB |
| Cetuximab | Sixth Affiliated Hospital, Sun Yat-sen University | P3 | BB |
| Oxaliplatin | Sixth Affiliated Hospital, Sun Yat-sen University | P3 | BB |
| Pertuzumab | SWOG Cancer Research Network | P2 | BB |
| Tipiracil | Sir Run Run Shaw Hospital | P2 | BB |
| Trifluridine | Sir Run Run Shaw Hospital | P2 | BB |
| Regorafenib | City of Hope Medical Center | P2 | BB |
+42 more in the Rectum Adenocarcinoma cohort
Other indications for Balstilimab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Colorectal Adenocarcinoma | — | P2 | BB · 66 |
| Colon Carcinoma | — | P2 | B · 60 |
| Colorectal Carcinoma | — | P2 | B · 60 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Balstilimab in Rectum Adenocarcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/balstilimab-rectum-adenocarcinoma
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