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Bendamustine

B-Cell Non-Hodgkin Lymphoma

Explore 306 assets in B-Cell Non-Hodgkin Lymphoma →
Floatz Rating
B59/100
Confidence
Indicative
v0.2
Sponsor
Swiss Cancer Institute
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
51High confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
NCT07166549CT.gov
Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial)
—Not Yet Recruiting———
NCT06191887CT.gov
B-Cell Activating Factor Receptor (BAFFR)-Based Chimeric Antigen Receptor T-Cells With Fludarabine and Cyclophosphamide Lymphodepletion for the Treatment of Relapsed or Refractory B-cell Hematologic Malignancies
—Recruiting———
NCT06415708CT.gov
Obinutuzumab Combined With Bendamustine in the Treatment of Mature B-cell Lymphoma
—Recruiting———
NCT05950334CT.gov
FT522 With Rituximab in Relapsed/Refractory B-Cell Lymphoma (FT522-101)
—Completed———
NCT04892277CT.gov
CD19-Directed CAR-T Cell Therapy for the Treatment of Relapsed/Refractory B Cell Malignancies
—Recruiting———
NCT04882163CT.gov
Study to Evaluate Tolerability of Iberdomide (CC-220) in Combination With Polatuzumab Vedotin Plus Rituximab or Tafasitamab or Rituximab Plus Chemotherapy in B-cell Lymphoma
—Withdrawn———
NCT04629729CT.gov
FT819 in Subjects With B-cell Malignancies
—Active Not Recruiting———
NCT04897477CT.gov
Azacytidine, Bendamustine, Piamprizumab in Refractory/Relapsed B-cell Non-Hodgkin's Lymphoma
—Unknown———
NCT04245722CT.gov
FT596 as a Monotherapy and in Combination With Anti-CD20 Monoclonal Antibodies
—Terminated———
NCT04023071CT.gov
FT516 in Subjects With Advanced Hematologic Malignancies
—Terminated———
Show 6 more trials
NCT03778073CT.gov
Study of Cosibelimab in Subjects With Relapsed or Refractory Lymphoma
—Terminated———
NCT03696784CT.gov
Anti-CD19 CAR-T Cells With Inducible Caspase 9 Safety Switch for B-cell Lymphoma
—Active Not Recruiting———
NCT03424122CT.gov
INCB050465 in Combination With Rituximab, Bendamustine and Rituximab, or Ibrutinib in Participants With Previously Treated B-Cell Lymphoma (CITADEL-112)
—Completed———
NCT02134262CT.gov
Gene Therapy for B-Cell Non-Hodgkin Lymphoma Using CD19 CAR Gene Transduced T Lymphocytes
—Unknown———
NCT01718691CT.gov
Efficacy and Safety Study of SyB L-0501 in Combination With Rituximab in Patients With Untreated, Low-grade B Cell Non-Hodgkin's Lymphoma and Mantle Cell Lymphoma
—Completed———
NCT01352312CT.gov
Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma
—Terminated———

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · B-Cell Non-Hodgkin Lymphoma

AssetSponsorPhaseRating
Bendamustine (this asset)Swiss Cancer InstituteP2B · 59
VindesineChildren's Cancer Group, ChinaP4BBB
Anti-Cd20/Cd3 Monoclonal Antibody Regn1979University of BirminghamP3BBB
CytarabineChildren's Cancer Group, ChinaP4BBB
CamustineFederal Research Institute of Pediatric Hematology, Oncology and ImmunologyP4BBB
ZanubrutinibThe First Affiliated Hospital of Soochow UniversityP4BBB
IsocyclophosphamideShanghai Junshi Bioscience Co., Ltd.P4BBB
Autologous Cd4+ And Cd8+ T Cells, Enriched From Peripheral Blood Mononuclear Cells (Pbmcs) Transduced With A Nonreplicative Self-Inactivating (Sin) Lentiviral Vector Encoding A Chimeric Antigen Receptor (Car) Consisting Of The Human Cd19-Specific Scfv, An Lgg4 Hinge Region, Cd28 Transmembrane Domain, Cd137 (4-1Bb) Co-Stimulatory Domain And Cd3 Zeta Signalling Domain, Under The Control Of A Hybrid Elongation Factor 1 Alpha (Ef1.Alpha.) And Human T Cell Leukemia Virus Type 1(Htlv-1) Regulatory Element Promoter And Woodchuck Hepatitis Virus Post-Transcriptional Regulatory Element (Wpre). The Vector Genome Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Co-Expressed With The Car And Cleaved From It By The T2A Self-Cleaving Peptide. The Vector Genome Also Contains A Splice Donor, A Fragment Of Gag, A Rev Response Element (Rre), A Mutated Central Polypurine Tract (Cppt), And A Splice AcceptorRuijin HospitalP4BBB
TacrolimusM.D. Anderson Cancer CenterP2BB

+42 more in the B-Cell Non-Hodgkin Lymphoma cohort

Other indications for Bendamustine

IndicationSponsorPhaseRating
Non-Hodgkin Lymphoma—P3BB · 70
B-Cell Chronic Lymphocytic Leukemia—P3BB · 70
Follicular Lymphoma—P4BB · 69

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Bendamustine in B-Cell Non-Hodgkin Lymphoma. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/bendamustine-b-cell-non-hodgkin-lymphoma

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