Bms-986353 Is An Investigational Cd19-Targeted Car T-Cell Product. The Cd19-Specific Car Consists Of A Single-Chain Variable Fragment (Scfv) Binding Domain Derived From A Cd19-Specific Monoclonal Antibody (Mab; Fmc63), An Igg-Derived Hinge Region, A Cd28 Transmembrane Domain, And The Cd137 (41Bb) And Cd3? Chain Signaling Domains. The Third-Generation Sin Lentiviral Vector, Which Encodes The Car Domains Described Above, Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Expressed Separately From The Cd19 Car On The T Cell Surface
Diffuse Large B-Cell Lymphoma
Explore 253 assets in Diffuse Large B-Cell Lymphoma →Floatz Rating
CC47/100
Confidence
Indicative
Sponsor
Juno Therapeutics, a Subsidiary of Celgene
Modality
Cell therapy
Development Phase
Phase 1
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
32Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT04231747CT.gov A Study of CC-97540, CD19-targeted NEX-T Chimeric Antigen Receptor (CAR) T Cells, in Subjects With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Diffuse Large B-Cell Lymphoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Bms-986353 Is An Investigational Cd19-Targeted Car T-Cell Product. The Cd19-Specific Car Consists Of A Single-Chain Variable Fragment (Scfv) Binding Domain Derived From A Cd19-Specific Monoclonal Antibody (Mab; Fmc63), An Igg-Derived Hinge Region, A Cd28 Transmembrane Domain, And The Cd137 (41Bb) And Cd3? Chain Signaling Domains. The Third-Generation Sin Lentiviral Vector, Which Encodes The Car Domains Described Above, Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Expressed Separately From The Cd19 Car On The T Cell Surface (this asset) | Juno Therapeutics, a Subsidiary of Celgene | P1 | CC · 47 |
| Vincristine Sulfate | National Cancer Institute (NCI) | P2/3 | A |
| Melphalan | Ruijin Hospital | P4 | BBB |
| Axicabtagene Ciloleucel | Ruijin Hospital | P4 | BBB |
| Adriamycin | Beth Israel Deaconess Medical Center | P4 | BBB |
| Nivestim | Ruijin Hospital | P3 | BBB |
| Prednisone | Beth Israel Deaconess Medical Center | P4 | BBB |
| Cyclosporin A | Fred Hutchinson Cancer Center | P3 | BBB |
| Rituximab | Beth Israel Deaconess Medical Center | P4 | BBB |
+42 more in the Diffuse Large B-Cell Lymphoma cohort
Other indications for Bms-986353 Is An Investigational Cd19-Targeted Car T-Cell Product. The Cd19-Specific Car Consists Of A Single-Chain Variable Fragment (Scfv) Binding Domain Derived From A Cd19-Specific Monoclonal Antibody (Mab; Fmc63), An Igg-Derived Hinge Region, A Cd28 Transmembrane Domain, And The Cd137 (41Bb) And Cd3? Chain Signaling Domains. The Third-Generation Sin Lentiviral Vector, Which Encodes The Car Domains Described Above, Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Expressed Separately From The Cd19 Car On The T Cell Surface
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Aggressive B-Cell Non-Hodgkin Lymphoma | — | P1 | CC · 47 |
| Non-Hodgkin Lymphoma | — | P1 | CC · 46 |
| Myasthenia Gravis | — | P1 | CC · 43 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Bms-986353 Is An Investigational Cd19-Targeted Car T-Cell Product. The Cd19-Specific Car Consists Of A Single-Chain Variable Fragment (Scfv) Binding Domain Derived From A Cd19-Specific Monoclonal Antibody (Mab; Fmc63), An Igg-Derived Hinge Region, A Cd28 Transmembrane Domain, And The Cd137 (41Bb) And Cd3? Chain Signaling Domains. The Third-Generation Sin Lentiviral Vector, Which Encodes The Car Domains Described Above, Also Encodes A Truncated Human Epidermal Growth Factor Receptor (Egfrt) That Is Expressed Separately From The Cd19 Car On The T Cell Surface in Diffuse Large B-Cell Lymphoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/bms-986353-is-an-investigational-cd19-targeted-car-t-cell-product-the-cd19-specific-car-consists-of-a-single-chain-variable-fragment-scfv-binding-domain-derived-from-a-cd19-specific-monoclonal-antibody-mab-fmc63-an-igg-derived-hinge-region-a-cd28-transmembrane-domain-and-the-cd137-41bb-and-cd3-chain-signaling-domains-the-third-generation-sin-lentiviral-vector-which-encodes-the-car-domains-described-above-also-encodes-a-truncated-human-epidermal-growth-factor-receptor-egfrt-that-is-expressed-separately-from-the-cd19-car-on-the-t-cell-surface-diffuse-large-b-cell-lymphoma
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