Botensilimab
Fibrolamellar Hepatocellular Carcinoma
Explore 26 assets in Fibrolamellar Hepatocellular Carcinoma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
Agenus Inc.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03860272CT.gov Fc-Engineered Anti-CTLA-4 Monoclonal Antibody in Advanced Cancer | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Fibrolamellar Hepatocellular Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Botensilimab (this asset) | Agenus Inc. | P1 | CC · 43 |
| Irinotecan | Children's Oncology Group | P3 | BB |
| Fluorouracilum | M.D. Anderson Cancer Center | P3 | BB |
| Nivolumab | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | P2 | B |
| Sorafenib | St. Jude Children's Research Hospital | P3 | B |
| Cis-Diamminedichloroplatinum Ii | Children's Oncology Group | P3 | B |
| Adriamycin | Children's Oncology Group | P3 | B |
| Etoposide | Children's Oncology Group | P3 | B |
| Cyclophosphamide | St. Jude Children's Research Hospital | P2 | B |
+29 more in the Fibrolamellar Hepatocellular Carcinoma cohort
Other indications for Botensilimab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Colorectal Adenocarcinoma | — | P2 | BB · 66 |
| Colorectal Cancer | — | P3 | B · 63 |
| Colorectal Carcinoma | — | P2 | B · 60 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Botensilimab in Fibrolamellar Hepatocellular Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/botensilimab-fibrolamellar-hepatocellular-carcinoma
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