Floatz Rating
B57/100
Confidence
Indicative
Sponsor
UNC Lineberger Comprehensive Cancer Center
Modality
antibody_drug_conjugate
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03264131CT.gov BV-CHEP Chemotherapy for Adult T-cell Leukemia or Lymphoma | — | Active Not Recruiting | — | — | — |
NCT02499627CT.gov Bendamustine Plus Brentuximab Vedotin in HL and CD30+ PTCL in First Salvage Setting | — | Terminated | — | — | — |
NCT02497131CT.gov Study on the Role of Brentuximab Vedotin as Single Agent in the Treatment of Relapsed/Refractory CD30+ PTCL Patients | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Lymphatic System Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Brentuximab Vedotin (this asset) | UNC Lineberger Comprehensive Cancer Center | P2 | B · 57 |
| Zilovertamab | Oncternal Therapeutics, Inc | P3 | B |
| Cyclophosphamide | UNC Lineberger Comprehensive Cancer Center | P2 | B |
| Ibrutinib | Oncternal Therapeutics, Inc | P3 | B |
| Bendamustine | UNC Lineberger Comprehensive Cancer Center | P2 | B |
| Ex Vivo-Activated Autologous Lymph Node Lymphocytes | M.D. Anderson Cancer Center | P2 | B |
| LF-PB | Chemi S.p.A. | P2 | B |
| Jcar-017 Cd19-Specific Chimeric Antigen Receptor | Juno Therapeutics, a Subsidiary of Celgene | P2 | B |
| Humax-Cd20 | M.D. Anderson Cancer Center | P2 | B |
+12 more in the Lymphatic System Disorder cohort
Other indications for Brentuximab Vedotin
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| T-Cell Non-Hodgkin Lymphoma | — | P4 | BBB · 73 |
| Anaplastic Large Cell Lymphoma | — | P3 | BBB · 72 |
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma | — | P3 | BB · 70 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Brentuximab Vedotin in Lymphatic System Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/brentuximab-vedotin-lymphatic-system-disorder
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