Floatz Rating
BB66/100
Confidence
Indicative
Sponsor
University of Rochester
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
51High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03016806CT.gov Umbilical Cord Blood Transplantation From Unrelated Donors | — | Recruiting | — | — | — |
NCT02349906CT.gov Treosulfan-based Versus Busulfan-based Conditioning in Paediatric Patients With Non-malignant Diseases | — | Completed | — | — | — |
NCT01596699CT.gov Pilot Trial of Clofarabine Added to Standard Busulfan and Fludarabine for Conditioning Prior to Allogeneic Hematopoietic Cell Transplantation | — | Terminated | — | — | — |
NCT01049854CT.gov CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant | — | Completed | — | — | — |
NCT00744692CT.gov Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Metabolic Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Busulfanum (this asset) | University of Rochester | P2 | BB · 66 |
| Liraglutide | Anders Fink-Jensen, MD, DMSci | P4 | A |
| Semaglutide | Nordsjaellands Hospital | P4 | A |
| Metformin | Jinnah Sindh Medical University | P4 | BBB |
| Tirzepatide | Washington University School of Medicine | P4 | BBB |
| Pravastatin | National Human Genome Research Institute (NHGRI) | P4 | BBB |
| Midazolam | Baskent University | P4 | BB |
| Retrovir | Kirby Institute | P4 | BB |
| Hydrochlorothiazide | Vanderbilt University Medical Center | P3 | BB |
+42 more in the Metabolic Disease cohort
Other indications for Busulfanum
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Myelodysplastic/Myeloproliferative Neoplasm | — | P2/3 | BBB · 76 |
| Graft Versus Host Disease | — | P4 | BBB · 74 |
| Disease Related To Hematopoietic Stem Cell Transplant | — | P3 | BBB · 74 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Busulfanum in Metabolic Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/busulfanum-metabolic-disease
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