Carboxylesterase-Expressing Allogeneic Neural Stem Cells
Grade III Glioma
Explore 23 assets in Grade III Glioma →Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
Cell therapy
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT02192359CT.gov Carboxylesterase-Expressing Allogeneic Neural Stem Cells and Irinotecan Hydrochloride in Treating Patients With Recurrent High-Grade Gliomas | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Grade III Glioma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Carboxylesterase-Expressing Allogeneic Neural Stem Cells (this asset) | City of Hope Medical Center | P1 | CC · 43 |
| Sorafenib | Virginia Commonwealth University | P2 | BB |
| Everolimus | Nationwide Children's Hospital | P2 | B |
| Perampanel | Mayo Clinic | P4 | B |
| Thioguanine Anhydrous | M.D. Anderson Cancer Center | P2 | B |
| Lomustine | M.D. Anderson Cancer Center | P2 | B |
| FET | Thomas Hope | P2 | B |
| Capecitabine | M.D. Anderson Cancer Center | P2 | B |
| Pamiparib | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | P1/2 | B |
+29 more in the Grade III Glioma cohort
Other indications for Carboxylesterase-Expressing Allogeneic Neural Stem Cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Anaplastic Oligodendroglioma | — | P1 | CC · 43 |
| Giant Cell Glioblastoma | — | P1 | CC · 43 |
| Anaplastic Astrocytoma | — | P1 | CC · 43 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Carboxylesterase-Expressing Allogeneic Neural Stem Cells in Grade III Glioma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/carboxylesterase-expressing-allogeneic-neural-stem-cells-grade-iii-glioma
Are you the sponsor?
Submit your data room for a Verified Rating. The public-data rating remains visible alongside.
Contact →