cd3/cd19 negative allogeneic hematopoietic stem cells
Chronic Granulomatous Disease
Explore 9 assets in Chronic Granulomatous Disease →Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
Paul Szabolcs
Modality
Cell therapy
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01852370CT.gov Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases | — | Enrolling By Invitation | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Chronic Granulomatous Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| cd3/cd19 negative allogeneic hematopoietic stem cells (this asset) | Paul Szabolcs | P1/2 | CCC · 48 |
| Thiotepa | University of Florida | P2 | BB |
| Cyclophosphamide | Roswell Park Cancer Institute | P2 | CCC |
| Fludarabine | Paul Szabolcs | P2 | CCC |
| Melphalan | Paul Szabolcs | P2 | CCC |
| Anti-Human T-Lymphocyte Immunoglobulin, Rabbit | Paul Szabolcs | P2 | CCC |
| Alemtuzumab | Paul Szabolcs | P2 | CCC |
| Abatacept Recombinant | Emory University | P1 | CC |
| Methotrexate | Fairview University Medical Center | N/A | D |
+6 more in the Chronic Granulomatous Disease cohort
Other indications for cd3/cd19 negative allogeneic hematopoietic stem cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hyper-IgE Syndrome | — | P1/2 | CCC · 48 |
| Severe Combined Immunodeficiency | — | P1/2 | CCC · 48 |
| Severe Congenital Neutropenia | — | P1/2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. cd3/cd19 negative allogeneic hematopoietic stem cells in Chronic Granulomatous Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/cd3cd19-negative-allogeneic-hematopoietic-stem-cells-chronic-granulomatous-disease
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