cd3/cd19 negative allogeneic hematopoietic stem cells
Common Variable Immunodeficiency
Explore 10 assets in Common Variable Immunodeficiency →Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
Paul Szabolcs
Modality
Cell therapy
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01852370CT.gov Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases | — | Enrolling By Invitation | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Common Variable Immunodeficiency
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| cd3/cd19 negative allogeneic hematopoietic stem cells (this asset) | Paul Szabolcs | P1/2 | CCC · 48 |
| Conestat Alfa | IMMUNOe Research Centers | P4 | BB |
| Thiotepa | University of Florida | P2 | BB |
| Human Immunoglobulins | Grifols Therapeutics LLC | P3 | B |
| Anti-Human T-Lymphocyte Immunoglobulin, Rabbit | Paul Szabolcs | P2 | CCC |
| Fludarabine | Paul Szabolcs | P2 | CCC |
| Alemtuzumab | Paul Szabolcs | P2 | CCC |
| Melphalan | Paul Szabolcs | P2 | CCC |
| Apilimod | National Institute of Allergy and Infectious Diseases (NIAID) | P1 | CC |
+10 more in the Common Variable Immunodeficiency cohort
Other indications for cd3/cd19 negative allogeneic hematopoietic stem cells
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hyper-IgE Syndrome | — | P1/2 | CCC · 48 |
| Severe Combined Immunodeficiency | — | P1/2 | CCC · 48 |
| Severe Congenital Neutropenia | — | P1/2 | CCC · 48 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. cd3/cd19 negative allogeneic hematopoietic stem cells in Common Variable Immunodeficiency. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/cd3cd19-negative-allogeneic-hematopoietic-stem-cells-common-variable-immunodeficiency
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