Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
National Center for Research Resources (NCRR)
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
35Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT00004310CT.gov Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder | — | Unknown | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Obsessive-Compulsive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Clomipramine (this asset) | National Center for Research Resources (NCRR) | P2 | CCC · 50 |
| Escitalopram | BeerYaakov Mental Health Center | P4 | BB |
| Fluoxetine | Massachusetts General Hospital | P4 | BB |
| Sertraline | Yang I. Pachankis, PhD | P4 | BB |
| Rituximab | Uppsala University Hospital | P2 | CCC |
| Paroxetine | Beijing Tongren Hospital | P1 | CC |
| Teonanacatl | Yale University | P1 | CC |
| Jnj-54135419 | Mark Niciu | Unk | D |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | Medical University of Gdansk | Unk | D |
+2 more in the Obsessive-Compulsive Disorder cohort
Other indications for Clomipramine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Physiological Malfunction Arising From Mental Factor | — | P3 | CCC · 54 |
| Anxiety Disorder | — | P3 | CCC · 54 |
| Dementia | — | P3 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Clomipramine in Obsessive-Compulsive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/clomipramine-obsessive-compulsive-disorder
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