Co-Methylcobinamide Dihydrogen Phosphate (Ester) Inner Salt 3'-Ester With 5,6-Dimethyl-1-.Alpha.-D-Ribofuranosyl-1H-Benzimidazole-.Kappa.N(Sip 3)
Amyotrophic Lateral Sclerosis
Explore 148 assets in Amyotrophic Lateral Sclerosis →Floatz Rating
CCC55/100
Confidence
Indicative
Sponsor
Eisai Co., Ltd.
Modality
Small molecule
Development Phase
Phase 3
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
49Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03548311CT.gov Clinical Trial of Ultra-high Dose Methylcobalamin for ALS | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Amyotrophic Lateral Sclerosis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Co-Methylcobinamide Dihydrogen Phosphate (Ester) Inner Salt 3'-Ester With 5,6-Dimethyl-1-.Alpha.-D-Ribofuranosyl-1H-Benzimidazole-.Kappa.N(Sip 3) (this asset) | Eisai Co., Ltd. | P3 | CCC · 55 |
| Taurursodiol | Amylyx Pharmaceuticals Inc. | P3 | BBB |
| Tofersen | Biogen | P4 | BBB |
| Riluzole | AB Science | P4 | BB |
| Diacetyl(N(4)-Methylthiosemicarbazonato) Copper (Ii) | Collaborative Medicinal Development Pty Limited | P2/3 | BB |
| Autologous Mesenchymal Stromal Cells Secreting Neurotrophic Factors | Brainstorm-Cell Therapeutics | P3 | BB |
| Kns-760704 | Knopp Biosciences | P3 | BB |
| mt-1186 | Tanabe Pharma Corporation | P3 | BB |
| Mexiletine | Bjorn Oskarsson, MD | P4 | BB |
+42 more in the Amyotrophic Lateral Sclerosis cohort
Other indications for Co-Methylcobinamide Dihydrogen Phosphate (Ester) Inner Salt 3'-Ester With 5,6-Dimethyl-1-.Alpha.-D-Ribofuranosyl-1H-Benzimidazole-.Kappa.N(Sip 3)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Breast Cancer | — | P4 | CCC · 52 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Co-Methylcobinamide Dihydrogen Phosphate (Ester) Inner Salt 3'-Ester With 5,6-Dimethyl-1-.Alpha.-D-Ribofuranosyl-1H-Benzimidazole-.Kappa.N(Sip 3) in Amyotrophic Lateral Sclerosis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/co-methylcobinamide-dihydrogen-phosphate-ester-inner-salt-3-ester-with-56-dimethyl-1-alpha-d-ribofuranosyl-1h-benzimidazole-kappansip-3-amyotrophic-lateral-sclerosis
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