Cpx-351
Acute Myeloid Leukemia With Multilineage Dysplasia
Explore 33 assets in Acute Myeloid Leukemia With Multilineage Dysplasia →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
UNKNOWN
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05554406CT.gov Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial) | — | Recruiting | — | — | — |
NCT05564390CT.gov MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial) | — | Recruiting | — | — | — |
NCT04802161CT.gov Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes | — | Active Not Recruiting | — | — | — |
NCT04269213CT.gov CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old | — | Active Not Recruiting | — | — | — |
NCT04231851CT.gov CPX-351 and Glasdegib for Newly Diagnosed Acute Myelogenous Leukemia With MDS Related Changes or Therapy-related Acute Myeloid Leukemia | — | Active Not Recruiting | — | — | — |
NCT03526926CT.gov A Post-Marketing Observational Study of VYXEOS™ | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Acute Myeloid Leukemia With Multilineage Dysplasia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Cpx-351 (this asset) | National Cancer Institute (NCI) | P2 | CCC · 53 |
| Cytarabine | National Cancer Institute (NCI) | P3 | BB |
| Etoposide | Institut de Recherches Internationales Servier | P2 | BB |
| Decitabine | National Cancer Institute (NCI) | P3 | BB |
| Cyclophosphamide | City of Hope Medical Center | P3 | BB |
| Fludarabine | National Cancer Institute (NCI) | P3 | BB |
| Ivosidenib | Institut de Recherches Internationales Servier | P3 | BB |
| Cyclosporin A | Case Comprehensive Cancer Center | P3 | BB |
| Busulfanum | National Cancer Institute (NCI) | P3 | BB |
+41 more in the Acute Myeloid Leukemia With Multilineage Dysplasia cohort
Other indications for Cpx-351
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome | — | P2 | BB · 67 |
| Myelodysplastic Syndrome | — | P2/3 | B · 63 |
| Acute Myeloid Leukemia | — | P4 | B · 61 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Cpx-351 in Acute Myeloid Leukemia With Multilineage Dysplasia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/cpx-351-acute-myeloid-leukemia-with-multilineage-dysplasia
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