Crizotinib
CDH1-Related Diffuse Gastric And Lobular Breast Cancer Syndrome
Explore 1 assets in CDH1-Related Diffuse Gastric And Lobular Breast Cancer Syndrome →Floatz Rating
B57/100
Confidence
Indicative
Sponsor
Royal Marsden NHS Foundation Trust
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
42Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03620643CT.gov Crizotinib in Lobular Breast, Diffuse Gastric and Triple Negative Lobular Breast Cancer or CDH1-mutated Solid Tumours | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · CDH1-Related Diffuse Gastric And Lobular Breast Cancer Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Crizotinib (this asset) | Royal Marsden NHS Foundation Trust | P2 | B · 57 |
| Fulvestrant | Royal Marsden NHS Foundation Trust | P2 | B |
| Tamoxifen | European Institute of Oncology | P2 | CCC |
Other indications for Crizotinib
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Anaplastic Large Cell Lymphoma | — | P4 | BBB · 75 |
| Inflammatory Myofibroblastic Tumor | — | P4 | BB · 69 |
| ALK-Positive Anaplastic Large Cell Lymphoma | — | P4 | BB · 68 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Crizotinib in CDH1-Related Diffuse Gastric And Lobular Breast Cancer Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/crizotinib-cdh1-related-diffuse-gastric-and-lobular-breast-cancer-syndrome
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