Floatz Rating
B62/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
47High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT01143402CT.gov Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye | — | Completed | — | — | — |
NCT01100528CT.gov Dacarbazine and Recombinant Interferon Alfa-2b in Treating Patients With Primary Uveal Melanoma With Genetic Imbalance | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Iris Melanoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dacarbazine (this asset) | National Cancer Institute (NCI) | P2 | B · 62 |
| Tyrosinase Peptide | National Cancer Institute (NCI) | P3 | BB |
| Sargramostim | National Cancer Institute (NCI) | P3 | BB |
| Cyclophosphamide | H. Lee Moffitt Cancer Center and Research Institute | P2 | B |
| Carboplatin | National Cancer Institute (NCI) | P2 | B |
| Ifa | National Cancer Institute (NCI) | P2 | B |
| gp100 antigen | National Cancer Institute (NCI) | P2 | B |
| Montanide Isa 51 | National Cancer Institute (NCI) | P2 | B |
| Cediranib | National Cancer Institute (NCI) | P2 | B |
+15 more in the Iris Melanoma cohort
Other indications for Dacarbazine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Metastatic Melanoma | — | P4 | BBB · 72 |
| Cutaneous Melanoma | — | P3 | BBB · 72 |
| Hodgkins Lymphoma | — | P4 | BB · 71 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dacarbazine in Iris Melanoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dacarbazine-iris-melanoma
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