Floatz Rating
BB66/100
Confidence
Indicative
Sponsor
Supernus Pharmaceuticals, Inc.
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
58High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05655520CT.gov A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Huntington's Disease | — | Terminated | — | — | — |
NCT05358821CT.gov 28-Day Study of SAGE-718 on Functioning Capacity in Participants With Huntington's Disease | — | Completed | — | — | — |
NCT05107128CT.gov A Study to Evaluate the Effect of SAGE-718 on Cognitive Function in Participants With Huntington's Disease (HD) | — | Completed | — | — | — |
NCT03787758CT.gov A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SAGE-718 Oral Solution in Patients With Huntington's Disease - Part B | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Huntington Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dalzanemdor (this asset) | Supernus Pharmaceuticals, Inc. | P3 | BB · 66 |
| Deutetrabenazine | Teva Branded Pharmaceutical Products R&D LLC | P4 | BBB |
| Tetrabenazine | William Ondo, MD | P4 | BBB |
| Tominersen | Hoffmann-La Roche | P3 | BBB |
| Latrepirdine | Medivation, Inc. | P3 | BB |
| Pridopidine | Prilenia | P3 | BB |
| MT-5199 | Neurocrine Biosciences | P3 | BB |
| Memantine | University of British Columbia | P4 | BB |
| Cellavita-Hd | Azidus Brasil | P2/3 | BB |
+42 more in the Huntington Disease cohort
Other indications for Dalzanemdor
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Cognitive Disorder | — | P2 | BB · 66 |
| Dementia | — | P2 | B · 62 |
| Parkinson Disease | — | P2 | CCC · 54 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dalzanemdor in Huntington Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dalzanemdor-huntington-disease
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