Daratumumab
Hematopoietic And Lymphoid Cell Neoplasm
Explore 115 assets in Hematopoietic And Lymphoid Cell Neoplasm →Floatz Rating
C36/100
Confidence
Indicative
Sponsor
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Modality
monoclonal_antibody
Development Phase
Early Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
24Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06398457CT.gov Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific Antibodies | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Hematopoietic And Lymphoid Cell Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Daratumumab (this asset) | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Early P1 | C · 36 |
| Pegloticase | M.D. Anderson Cancer Center | P4 | BB |
| Nivestim | St. Jude Children's Research Hospital | P2 | BB |
| Rasburicase | M.D. Anderson Cancer Center | P4 | BB |
| Cyclosporin A | Children's Oncology Group | P3 | BB |
| Prednisone | M.D. Anderson Cancer Center | P2 | BB |
| Hydromorphon | M.D. Anderson Cancer Center | P4 | BB |
| Tacrolimus | Fred Hutchinson Cancer Center | P2 | BB |
| Fludarabine | National Cancer Institute (NCI) | P3 | BB |
+42 more in the Hematopoietic And Lymphoid Cell Neoplasm cohort
Other indications for Daratumumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Plasma Cell Myeloma | — | P4 | BB · 69 |
| Smoldering Plasma Cell Myeloma | — | P3 | BB · 65 |
| Diffuse Large B-Cell Lymphoma | — | P2 | BB · 65 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Daratumumab in Hematopoietic And Lymphoid Cell Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/daratumumab-hematopoietic-and-lymphoid-cell-neoplasm
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