Floatz Rating
B63/100
Confidence
Indicative
Sponsor
Mclean Hospital
Modality
UNKNOWN
Development Phase
Phase 4 / Approved
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
62High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07593222CT.gov Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder | — | Not Yet Recruiting | — | — | — |
NCT07560878CT.gov Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression | — | Recruiting | — | — | — |
NCT05591677CT.gov D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT) | — | Active Not Recruiting | — | — | — |
NCT05731323CT.gov D-Cycloserine+iTBS PK Study | — | Completed | — | — | — |
NCT03937596CT.gov Adjunctive D-Cycloserine in Major Depressive Disorder | — | Completed | — | — | — |
NCT03062150CT.gov Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression | — | Completed | — | — | — |
NCT02772211CT.gov D-cycloserine for Relapse Prevention Following Intravenous Ketamine in Treatment-resistant Depression | — | Unknown | — | — | — |
NCT02376257CT.gov Improving Therapeutic Learning in Depression: Proof of Concept | — | Completed | — | — | — |
NCT00869765CT.gov Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depression | — | Completed | — | — | — |
NCT00408031CT.gov D-cycloserine for Major Depressive Disorder | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Major Depressive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dcs (this asset) | Mclean Hospital | Approved | B · 63 |
| Selegiline | Corium Innovations, Inc. | P4 | BBB |
| Risperidone | Johns Hopkins University | P4 | BBB |
| Edivoxetine | Eli Lilly and Company | P3 | BBB |
| Brexpiprazole | Nova Scotia Health Authority | P4 | BBB |
| (1S,2R)-MILNACIPRAN | Allergan | P4 | BBB |
| Vortioxetine | Mayo Clinic | P4 | BBB |
| Amitriptyline | e-Therapeutics PLC | P4 | BBB |
| 17.BETA.-(1-KETOETHYL)-.DELTA. SUP(5)-ANDROSTEN-3.BETA.-OL | Massachusetts General Hospital | P4 | BBB |
+42 more in the Major Depressive Disorder cohort
Other indications for Dcs
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Bipolar Disorder | — | P4 | BB · 69 |
| Schizophrenia | — | P4 | BB · 68 |
| Delusional Disorder | — | P4 | BB · 67 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dcs in Major Depressive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dcs-major-depressive-disorder
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