Floatz Rating
BB64/100
Confidence
Indicative
Sponsor
Lingjiang Li
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
59High confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03932825CT.gov Nitrous Oxide for Major Depressive Disorder | — | Completed | — | — | — |
NCT03869736CT.gov Nitrous Oxide for the Treatment of Major Depressive Disorder | — | Completed | — | — | — |
NCT03736538CT.gov Nitrous Oxide- Suicidal Ideation | — | Enrolling By Invitation | — | — | — |
NCT02994433CT.gov NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits | — | Recruiting | — | — | — |
NCT03283670CT.gov Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies | — | Completed | — | — | — |
NCT02139540CT.gov Nitrous Oxide as Treatment for Major Depression - a Pilot Study | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
73High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Depressive Disorder
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dinitrogen Monoxide (this asset) | Lingjiang Li | P2 | BB · 64 |
| Brexpiprazole | Dr. Albert Kar-Kin Chung | P4 | A |
| Jnj-54135419 | Chinese PLA General Hospital | P4 | BBB |
| Saredutant | Sanofi | P3 | BBB |
| (±)-2-(O-Chlorophenyl)-2-(Methylamino)Cyclohexanone | VA Office of Research and Development | P4 | BBB |
| Lithium, Elemental | Rakitzi, Stavroula | P4 | BBB |
| Fluoxetine | University of Oxford | P4 | BBB |
| Citalopram | Western University, Canada | P4 | BBB |
| Paroxetine | Brigham and Women's Hospital | P4 | BBB |
+42 more in the Depressive Disorder cohort
Other indications for Dinitrogen Monoxide
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Epilepsy | — | P4 | BB · 69 |
| Neurofibromatosis | — | P4 | BB · 69 |
| Hydrocephalus | — | P4 | BB · 69 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dinitrogen Monoxide in Depressive Disorder. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dinitrogen-monoxide-depressive-disorder-15604
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