Floatz Rating
C38/100
Confidence
Indicative
Sponsor
Addex Pharma S.A.
Modality
Small molecule
Development Phase
Phase 2/3
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
23Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05116813CT.gov Open-label Safety Study of Dipraglurant (ADX48621) in Patients With Parkinson's Disease Receiving Levodopa-based Therapy | — | Terminated | — | — | — |
NCT04857359CT.gov Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Tardive Dyskinesia
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dipraglurant (this asset) | Addex Pharma S.A. | P2/3 | C · 38 |
| MT-5199 | Neurocrine Biosciences | P4 | BBB |
| Ginkgo Biloba | Beijing HuiLongGuan Hospital | P3 | BB |
| Varenicline | Corporal Michael J. Crescenz VA Medical Center | P4 | B |
| Pyridoxol | Beersheva Mental Health Center | P3 | B |
| Safinamide | Zambon SpA | P3 | B |
| 1H-INDOLE-1-CARBOXYLIC ACID, OCTAHYDRO-4-HYDROXY-4-((3-METHYLPHENYL)ETHYNYL)-, METHYL ESTER, (3AR,4S,7AR)- | Novartis Pharmaceuticals | P2 | B |
| [14c] lpm3770164 | Luye Pharma Group Ltd. | P1 | CCC |
| Pyridoxal 5'-Phosphate | Medicure | P2 | CCC |
+6 more in the Tardive Dyskinesia cohort
Other indications for Dipraglurant
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Parkinson Disease | — | P2/3 | CC · 42 |
| Drug-Induced Dyskinesia | — | P2/3 | C · 38 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dipraglurant in Tardive Dyskinesia. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dipraglurant-tardive-dyskinesia
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