Floatz logo
Floatz Rating
BB67/100
Confidence
Indicative
v0.2
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 3
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
70High confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
QLC5508 in Participants With Metastatic Prostate Cancer
Not Yet Recruiting
Phase III Randomized International Open Label Clinical Trial of Treatment Intensification With Docetaxel Plus Apalutamide in Patients With Metastatic Hormone-sensitive Prostate Cancer Who Did Not Achieve a Deep PSA Response After Initial Treatment With Apalutamide: REINFORCE Trial.
Recruiting
Safety and Efficacy of Docetaxel, Darolutamide, and Homoharringtonine Combined With Androgen Deprivation Therapy in Neoadjuvant Treatment of High-Risk Prostate Cancer: A Multicenter Prospective, Single-Arm Clinical Study
Not Yet Recruiting
A Study to Learn How Men With Advanced Prostate Cancer Respond to Treatment With Darolutamide and Hormone Therapy, With or Without Chemotherapy, in Real-world Medical Practice
Active Not Recruiting
Study to Assess the Effect of OCT-598 in Patients With Advanced Solid Tumors
Recruiting
Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial
Recruiting
Study on Triple Therapy Combined With HIFU for High-Tumor-Burden mHSPC
Recruiting
A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)
Recruiting
HS-10502 Combination Treatment in Patients With Advanced Solid Tumors
Recruiting
PSA Biochemical Response as Prognostic Factor in Metastatic Castration-Sensitive Prostate Cancer
Recruiting
Show 147 more trials
The Case of "Triple" Versus "Double" Therapy for Patients With High Volume Metastatic Hormone Sensitive Prostate Cancer
Recruiting
A Study of HRS-5041 Tablets Combined With Antitumor Therapy in Subjects With Advanced Prostate Cancer
Recruiting
Docetaxel Alone or in Combination With Enzalutamide for mCRPC Previously Treated With Abiraterone at mHSPC Stage
Unknown
Outcomes of Local Treatment for Oligometastatic Prostate Cancer Diagnosed Using PSMA PET Imaging: OLIGOMET Study
Not Yet Recruiting
Genomic Biomarker-guided Neoadjuvant Therapy for Prostate Cancer (SEGNO)
Recruiting
Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular Tracers
Recruiting
A Study of Lorigerlimab With Docetaxel or Docetaxel Alone in Participants With Metastatic Castration-Resistant Prostate Cancer
Completed
Vudalimab (XmAb20717) in Combination With Standard of Care Treatment in Patients With Metastatic Castration Sensitive Prostate Cancer
Terminated
A Study of Pasritamig (JNJ-78278343) in Combination With Other Agents for Metastatic Prostate Cancer
Recruiting
Study of Capivasertib + Docetaxel vs Placebo + Docetaxel as Treatment for Metastatic Castration Resistant Prostate Cancer (mCRPC)
Active Not Recruiting
First Strike, Second Strike Therapies for High Risk Metastatic Castration Sensitive Prostate Cancer
Active Not Recruiting
Genomic Biomarker-Selected Umbrella Neoadjuvant Study for High Risk Localized Prostate Cancer
Recruiting
177 LuPSMA-617 vs Docetaxel in Metastatic Castration Resistant and PSMA-Positive Prostate Cancer
Active Not Recruiting
PSMA PET/CT-Based Multimodal Model for Predicting Response to First-Line Therapy in mHSPC.
Completed
Neoadjuvant Chemo-hormonal Therapy Combined With Radical Prostatectomy for Locally Advanced Prostate Cancer
Unknown
Biomarker Analysis of Castration-resistant Prostate Cancer Undergoing Treatment With Docetaxel Followed by Enzalutamide
Unknown
M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Active Not Recruiting
A Parallel Arm Phase 1b/2a Study of DKN-01 as Monotherapy or in Combination With Docetaxel for the Treatment of Advanced Prostate Cancer With Elevated DKK1
Terminated
A Trial of Immunotherapy Strategies in Metastatic Hormone-sensitive Prostate Cancer
Unknown
Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate
Active Not Recruiting
PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery
Completed
Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
Recruiting
A Study to Test Radium-223 With Docetaxel in Patients With Prostate Cancer
Active Not Recruiting
A Salvage Trial of AR Inhibition With ADT and Apalutamide With Radiation Therapy Followed by Docetaxel in Men With PSA Recurrent Prostate Cancer After Radical Prostatectomy (STARTAR)
Completed
Toxicity & Pharmacokinetics of 2 & 3-weekly Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Withdrawn
Pilot Trial of Chemohormonal Therapy Followed by Prostatectomy in High Risk Prostate Cancer
Completed
An Investigational Immunotherapy Study of Nivolumab in Combination With Rucaparib, Docetaxel, or Enzalutamide in Metastatic Castration-resistant Prostate Cancer
Completed
A Trial of Androgen Deprivation, Docetaxel, and Enzalutamide for Metastatic Prostate Cancer
Active Not Recruiting
A Study of Docetaxel + ARN-509 in Castration-Resistant Prostate Cancer
Terminated
Cohorts of Docetaxel or Cabazitaxel in Combination With the Potent CYP3A4 Inhibitor, Clarithromycin
Terminated
Evaluation of Clinical Outcomes of Chemotherapy or Androgen-receptor Targeting Agent (Alone or Combined) or Radiotherapy on Primary Tumor in Addition to Androgen Deprivation Therapy in HOrmone-Sensitive Metastatic Prostate Cancer Patients
Recruiting
Docetaxel Followed by Provenge in Metastatic Prostate Cancer
Withdrawn
Provenge Followed by Docetaxel in Castration-Resistant Prostate Cancer
Withdrawn
Darolutamide in Addition to Standard Androgen Deprivation Therapy and Docetaxel in Metastatic Hormone-Sensitive Prostate Cancer
Completed
Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer
Terminated
Docetaxel/Prednisone Versus Docetaxel/Prednisone and Enzalutamide in Castration-Resistant Prostate Cancer
Terminated
Docetaxel and PROSTVAC for Metastatic Castration-Sensitive Prostate Cancer
Completed
LEE011 (Ribociclib) in Combination With Docetaxel Plus Prednisone in mCRPC
Completed
Hormonal Therapy and Chemotherapy Followed by Prostatectomy in Patients With Prostate Cancer
Terminated
Micro RNAs to Predict Response to Androgen Deprivation Therapy
Completed
A Randomised Trial of Cabazitaxel, Docetaxel, Mitoxantrone or Satraplatin (CDMS) Plus Surgery for Prostate Cancer Patients
Recruiting
LDE225 + Docetaxel/Prednisone for Adv/Met Castrate Resistant Prostate Cancer w/ Disease Progression After Docetaxel
Withdrawn
A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors
Completed
Reolysin Combined With Docetaxel and Prednisone or Docetaxel and Prednisone Alone in Metastatic Castration Resistant Prostate Cancer
Completed
External Beam Radiation With or Without Chemotherapy to Treat High Risk Prostate Cancer
Terminated
Phase II Study of DCVAC/PCa Added to Standard Chemotherapy for Men With Metastatic Castration Resistant Prostate Cancer
Completed
Docetaxel, Prednisone, and Pasireotide in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Completed
A Safety Study of Abiraterone Acetate Administered in Combination With Docetaxel in Patients With Metastatic Castration-Resistant Prostate Cancer (mCRPC)
Completed
Pazopanib, Docetaxel, Prednisone Prostate
Completed
Docetaxel + Prednisone With or Without Radiation for Castrate Resistant Prostate Cancer
Withdrawn
Feasibility of a Chemotherapy With Docetaxel-Prednisone for Castration-resistant Metastatic Prostate Cancer Elderly Patients
Completed
Comparison of Docetaxel/Prednisone to Docetaxel/Prednisone in Combination With OGX-011 in Men With Prostate Cancer
Completed
Docetaxel and Prednisone With or Without Vaccine Therapy in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer
Terminated
Study of TAK-700 in Combination With Docetaxel and Prednisone in Men With Metastatic Castration-Resistant Prostate Cancer
Completed
Efficacy and Safety Study of LE-DT to Treat Metastatic Castrate Resistant Prostate Cancer
Withdrawn
Phase I Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate Cancer
Terminated
Safety Study & Effectiveness of Docetaxel With RAD001 and Bevacizumab in Men With Advanced Prostate Cancer
Completed
Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate Cancer Patients
Terminated
Docetaxel/Prednisone Plus Fractionated 177Lu- J591 Antibody for Metastatic, Castrate-resistant Prostate Cancer
Completed
Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer
Terminated
A Study to Determine the Maximum Tolerated Dose of Elesclomol Sodium Given With a Fixed Dose of Docetaxel and Prednisone in Patients With Metastatic Prostate Cancer
Completed
S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
Withdrawn
Androgen Suppression and Radiation With/Out Docetaxel in High-Risk Localized Prostate Cancer
Terminated
Docetaxel and Cetuximab in Treating Patients With Metastatic Prostate Cancer
Completed
Radiation Therapy, Androgen Suppression, and Docetaxel in Treating Patients With High-Risk Prostate Cancer Who Have Undergone Radical Prostatectomy
Completed
A Study of an Experimental Chemotherapy Combination to Treat Hormone Refractory Prostate Cancer
Completed
Docetaxel and Immunotherapy Prior to Prostatectomy for High-Risk Prostate Cancer
Terminated
A Dose Finding Study With I.V. Panobinostat (LBH589), Docetaxel, and Prednisone in Patients With Hormone Refractory Prostate Cancer
Completed
A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) and Docetaxel in Metastatic Hormone Resistant Prostate Cancer
Completed
Docetaxel and Prednisone With or Without Cediranib in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
Terminated
Sorafenib and Docetaxel in Patients With Prostate Cancer That Did Not Respond to Previous Hormone Therapy
Completed
A Phase 2 Study With Enzastaurin Plus Chemotherapy or Placebo Plus Chemotherapy for Prostate Cancer Patients
Completed
A Study to Evaluate the Safety, Tolerability, and Activity of Lonafarnib and Docetaxel (Study P04467AM1)(TERMINATED)
Terminated
A Phase I/II Study of Azacitidine, Docetaxel, and Prednisone for Metastatic Prostate Cancer Patients
Terminated
An Open-Label Study of YM155 + Docetaxel in Subjects With Advanced Hormone Refractory Prostate Cancer and Other Solid Tumors
Completed
Intermittent Chemotherapy With or Without Granulocyte-macrophage Colony-stimulating Factor (GM-CSF) for Metastatic Hormone Refractory Prostate Cancer (HRPC)
Completed
Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and Relapsed Solid Malignancies.
Terminated
A Study Comparing Oral Picoplatin With Intravenous Picoplatin in Subjects With Solid Tumors
Completed
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer
Completed
Pharmacokinetic Study of BAY43-9006 and Taxotere to Treat Patient With Prostatic Cancer
Completed
S0421, Docetaxel and Prednisone With or Without Atrasentan in Treating Patients With Stage IV Prostate Cancer and Bone Metastases That Did Not Respond to Previous Hormone Therapy
Completed
Evaluation of Safety and Feasibility of OGX-011 in Combination With 2nd-line Chemotherapy in Patients With HRPC
Completed
Radiation Therapy and Docetaxel in Treating Patients Who Are Undergoing Surgery for Localized Prostate Cancer
Terminated
Phase I Study of ZD4054 (Zibotentan) and Docetaxel in Patients With Metastatic HRPC
Completed
Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer
Terminated
DN-101 in Combination With Docetaxel in Androgen-Independent Prostate Cancer (AIPC) (AIPC Study of Calcitriol Enhancing Taxotere [ASCENT-2])
Terminated
E3-Hormone Refractory Prostrate Cancer Taxotere Combination
Completed
The Use of RAD001 With Docetaxel in the Treatment of Metastatic, Androgen Independent Prostate Cancer
Completed
Safety Study of Imexon Plus Docetaxel in Lung, Breast or Prostate Cancer Patients
Completed
Docetaxel and Prednisone With/Out OGX-011 in Recurrent or Metastatic Prostate Cancer That Did Not Respond to Previous Hormone Therapy
Completed
Pemetrexed Disodium and Docetaxel in Treating Patients With Advanced Solid Tumors
Completed
Pilot Efficacy Study of PI-88 With Docetaxel to Treat Prostate Cancer
Completed
A Study of Imatinib and Docetaxel in Prostate Cancer
Completed
Systemic Therapy in Advancing or Metastatic Prostate Cancer: Evaluation of Drug Efficacy
Active Not Recruiting
Docetaxel in Combination With GVAX ® Immunotherapy Versus Docetaxel and Prednisone in Prostate Cancer Patients
Terminated
Neoadjuvant Hormones + Docetaxel in Node-Positive Prostate Cancer
Completed
Docetaxel (Taxotere) and Imatinib Mesylate (Gleevec) in Hormone Refractory Prostate Cancer
Terminated
Study of Bortezomib and Docetaxel for Patients With Hormone Refractory Prostate Cancer
Terminated
Docetaxel, Prednisone, and Vatalanib in Treating Patients With Advanced Prostate Cancer
Terminated
GTI-2040, Docetaxel, and Prednisone in Treating Patients With Prostate Cancer
Completed
Study of Oxaliplatin and Taxotere in Prostate Cancer
Completed
Hormone Therapy and Docetaxel or Hormone Therapy Alone in Treating Patients With Metastatic Prostate Cancer
Completed
Radiation Therapy, Docetaxel, and Hormone Therapy in High-Risk Locally Advanced Metastasized Prostate Cancer
Completed
Adjuvant Docetaxel and Estramustine Phosphate for High Risk Localized Prostate Cancer
Completed
GVAX® Vaccine for Prostate Cancer vs Docetaxel & Prednisone in Patients With Metastatic Hormone-Refractory Prostate Cancer
Terminated
Docetaxel With or Without Oblimersen in Treating Patients With Hormone-Refractory Adenocarcinoma (Cancer) of the Prostate
Completed
Docetaxel, Estramustine and Short Term Androgen Withdrawal for Patients With a Rising PSA After Local Treatment
Completed
Docetaxel, Estramustine, and Thalidomide in Treating Patients With Androgen-Independent Metastatic Adenocarcinoma of the Prostate
Completed
Study of Taxotere and Doxil to Treat Advanced Androgen-Independent Prostate Cancer
Completed
Trial of Docetaxel-Samarium in Patients With Hormone-Refractory Advanced Prostate Cancer
Terminated
MEDI-522 in the Treatment of Patients With Metastatic Androgen-Independent Prostate Cancer
Completed
Hormone Therapy Compared With Combination Chemotherapy in Treating Patients With Prostate Cancer
Completed
GTI-2040 and Docetaxel in Treating Patients With Recurrent, Metastatic, or Unresectable Locally Advanced Non-Small Cell Lung Cancer, Prostate Cancer, or Other Solid Tumors
Completed
Adjuvant Taxotere in Patients With High Risk Prostate Cancer Post Prostatectomy and Radiation
Completed
Docetaxel With Rapid Hormonal Cycling as a Treatment for Patients With Prostate Cancer
Completed
Hormonal Ablation, Imatinib Mesylate and Docetaxel for Patients With Prostate Cancer
Completed
Docetaxel With or Without Imatinib Mesylate in Treating Patients With Androgen-Independent Prostate Cancer and Bone Metastases
Completed
Safety and Effectiveness Study of Docetaxel and ZD1839 Followed by Removal of the Prostate to Treat Prostate Cancer
Completed
Docetaxel and Imatinib Mesylate in Treating Patients With Androgen-Independent Prostate Cancer and Bone Metastases That Progressed on the Docetaxel and Placebo Group of MDA-ID-030008
Completed
OGX-011 and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Solid Tumors
Completed
Combination Chemotherapy in Treating Patients With Metastatic or Unresectable Solid Tumors
Completed
Docetaxel and Diethylstilbestrol in the Treatment of Androgen Independent Prostate Cancer
Completed
Hormone Therapy With or Without Docetaxel And Estramustine in Treating Patients With Prostate Cancer That is Locally Advanced or At High Risk of Relapse
Completed
Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Hormone Therapy
Terminated
Docetaxel, Estramustine, and Exisulind in Treating Patients With Metastatic Prostate Cancer That Has Not Responded to Hormone Therapy
Completed
Comparison Study of MDX-010 (CTLA-4) Alone and Combined With Docetaxel in the Treatment of Patients With Hormone Refractory Prostate Cancer
Completed
Hormone Therapy Plus Chemotherapy in Treating Patients With Prostate Cancer
Completed
Immunotherapy After Chemotherapy for Patients With Hormone Refractory Metastatic Prostate Cancer
Completed
ASCENT: Androgen Independent Prostate Cancer Study of Calcitriol Enhancing Taxotere
Unknown
Vaccine Therapy With or Without Docetaxel in Treating Patients With Metastatic Prostate Cancer
Completed
A Phase II Trial of Combination Therapy With Celecoxib and Taxotere for the Treatment of Stage D3 Prostate Cancer
Unknown
Study of Docetaxel With Doxercalciferol or Placebo for Advanced Prostate Cancer
Terminated
Chemotherapy With or Without Strontium-89 in Treating Patients With Prostate Cancer
Terminated
Phase I Trial of Fixed Dose STI571 (Imatinib Mesylate) With Escalating Doses of Docetaxel in Patients With Metastatic Androgen-Independent Prostate Cancer
Completed
Docetaxel, Estramustine, and Thalidomide in Treating Patients With Prostate Cancer Previously Treated With Hormone Therapy
Completed
Combination Chemotherapy Plus Bevacizumab in Treating Patients With Metastatic Prostate Cancer
Completed
Docetaxel Followed by Radical Prostatectomy in Patients With High Risk Localized Prostate Cancer
Completed
Combination Chemotherapy Followed by Surgery in Treating Patients With Localized Prostate Cancer
Completed
Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer
Completed
Combination Chemotherapy Plus Filgrastim in Treating Patients With Stage IV Prostate Cancer That Has Not Responded to Hormone Therapy
Completed
Docetaxel With or Without Thalidomide in Treating Patients With Metastatic Prostate Cancer
Completed
S9916, Combination Therapy in Treating Patients With Advanced Prostate Cancer That Has Not Responded to Hormone Therapy
Completed
Estramustine, Docetaxel, and Carboplatin in Treating Patients With Prostate Cancer That Has Not Responded to Hormone Therapy
Completed
Combination Chemotherapy in Treating Patients With Advanced Prostate Cancer
Unknown
Docetaxel Plus Estramustine in Treating Patients With Metastatic Prostate Cancer
Unknown
Chemotherapy in Treating Patients With Solid Tumors
Completed
Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer (CRPC)
Withdrawn

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
59High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · Prostate Cancer

AssetSponsorPhaseRating
Docetaxel (this asset)National Cancer Institute (NCI)P3BB · 67
AvodartBay State Clinical Trials, Inc.P4BBB
DesfluranePeter MacCallum Cancer Centre, AustraliaP4BBB
PropofolPeter MacCallum Cancer Centre, AustraliaP4BBB
DegarelixBayerP4BBB
Flotufolastat F 18Washington University School of MedicineP4BB
AVOLVEMasonic Cancer Center, University of MinnesotaP4BB
EstramustineThe University of Texas Health Science Center, HoustonP3BB
PasireotideRECORDATI GROUPP4BB

+42 more in the Prostate Cancer cohort

Other indications for Docetaxel

IndicationSponsorPhaseRating
Prostate NeoplasmP4BBB · 73
Pancreatic AdenocarcinomaP2BBB · 72
Cancer Of Unknown Primary SiteP2BBB · 72

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Docetaxel in Prostate Cancer. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 11, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/docetaxel-prostate-cancer

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