Floatz Rating
CC43/100
Confidence
Indicative
Sponsor
UNC Lineberger Comprehensive Cancer Center
Modality
Small molecule
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
36Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT05542407CT.gov ONC201 and Atezolizumab in Obesity-Driven Endometrial Cancer | — | Recruiting | — | — | — |
NCT03394027CT.gov ONC201 in Recurrent/Refractory Metastatic Breast Cancer and Advanced Endometrial Carcinoma | — | Completed | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Endometrial Carcinoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Dordaviprone (this asset) | UNC Lineberger Comprehensive Cancer Center | P2 | CC · 43 |
| Adriamycin | AstraZeneca | P3 | BB |
| Indocyanine Green | Istanbul University | P4 | BB |
| Palbociclib | University Medical Center Groningen | P4 | B |
| Olaparib | Qilu Pharmaceutical Co., Ltd. | P4 | B |
| Docetaxel | Merck Sharp & Dohme LLC | P3 | B |
| Carboplatin | Qilu Pharmaceutical Co., Ltd. | P3 | B |
| Nivestim | Mayo Clinic | P3 | B |
| Rilvegostomig | AstraZeneca | P3 | B |
+42 more in the Endometrial Carcinoma cohort
Other indications for Dordaviprone
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Glioma | — | P2 | CC · 45 |
| Malignant Epithelial Tumor Of Ovary | — | P2 | CC · 45 |
| Fallopian Tube Carcinoma | — | P2 | CC · 45 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Dordaviprone in Endometrial Carcinoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 14, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/dordaviprone-endometrial-carcinoma
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