Floatz Rating
CC41/100
Confidence
Indicative
Sponsor
City of Hope Medical Center
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06996119CT.gov Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Graft Versus Host Disease
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Emapalumab (this asset) | City of Hope Medical Center | P1 | CC · 41 |
| Cyclophosphamide | City of Hope Medical Center | P4 | BBB |
| Busulfanum | City of Hope Medical Center | P4 | BBB |
| Thiotepa | Memorial Sloan Kettering Cancer Center | P4 | BBB |
| Nivestim | City of Hope Medical Center | P4 | BBB |
| Cyclosporin A | Memorial Sloan Kettering Cancer Center | P3 | BB |
| Ruxolitinib | Jonathan Brammer | P4 | BB |
| Tacrolimus | City of Hope Medical Center | P3 | BB |
| Fludarabine | City of Hope Medical Center | P3 | BB |
+41 more in the Graft Versus Host Disease cohort
Other indications for Emapalumab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Non-Hodgkin Lymphoma | — | P2 | CCC · 53 |
| Primary Mediastinal Large B-Cell Lymphoma | — | P2 | CCC · 53 |
| Large B-Cell Lymphoma | — | P2 | CCC · 51 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Emapalumab in Graft Versus Host Disease. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/emapalumab-graft-versus-host-disease
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