Floatz Rating
CCC50/100
Confidence
Indicative
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Modality
monoclonal_antibody
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
40Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06676033CT.gov Epcoritamab in Chronic Lymphocytic Leukemia and Richter Syndrome | — | Active Not Recruiting | — | — | — |
NCT04623541CT.gov Safety and Efficacy Study of Epcoritamab in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia and Richter's Syndrome | — | Active Not Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Richter Transformation
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Epcoritamab (this asset) | National Heart, Lung, and Blood Institute (NHLBI) | P1/2 | CCC · 50 |
| Obinutuzumab | Christine Ryan | P2 | BB |
| Ibrutinib | City of Hope Medical Center | P2 | BB |
| Venetoclax | Northwestern University | P2 | BB |
| Adriamycin | SWOG Cancer Research Network | P3 | BB |
| Humax-Cd20 | University of Oxford | P2 | BB |
| Cyclophosphamide | SWOG Cancer Research Network | P3 | BB |
| Rituximab | SWOG Cancer Research Network | P3 | BB |
| Pirtobrutinib | SWOG Cancer Research Network | P3 | BB |
+42 more in the Richter Transformation cohort
Other indications for Epcoritamab
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | — | P2 | BB · 65 |
| Diffuse Large B-Cell Lymphoma | — | P3 | BB · 65 |
| Primary Central Nervous System Lymphoma | — | P2 | B · 60 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Epcoritamab in Richter Transformation. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/epcoritamab-richter-transformation
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