Etx-19477
Breast-Ovarian Cancer, Familial, Susceptibility To, 1
Explore 16 assets in Breast-Ovarian Cancer, Familial, Susceptibility To, 1 →Floatz Rating
CC45/100
Confidence
Indicative
Sponsor
858 Therapeutics, Inc.
Modality
UNKNOWN
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06395519CT.gov A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
81High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Breast-Ovarian Cancer, Familial, Susceptibility To, 1
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Etx-19477 (this asset) | 858 Therapeutics, Inc. | P1/2 | CC · 45 |
| Ovitrelle | University Hospital, Ghent | P4 | BB |
| Cis-Diamminedichloroplatinum Ii | The University of Texas Health Science Center at San Antonio | P3 | B |
| Niraparib | University of California, San Francisco | P2 | B |
| Olaparib | GBG Forschungs GmbH | P2 | B |
| Irinotecan | University of California, San Francisco | P2 | B |
| Denosumab | Alliance for Clinical Trials in Oncology | P3 | B |
| Docetaxel | Spanish Lung Cancer Group | P3 | B |
| Elacestrant | GBG Forschungs GmbH | P2 | CCC |
+17 more in the Breast-Ovarian Cancer, Familial, Susceptibility To, 1 cohort
Other indications for Etx-19477
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Estrogen-Receptor Positive Breast Cancer | — | P1/2 | CC · 47 |
| Castration-Resistant Prostate Carcinoma | — | P1/2 | CC · 47 |
| BRCA2-Related Cancer Predisposition | — | P1/2 | CC · 45 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Etx-19477 in Breast-Ovarian Cancer, Familial, Susceptibility To, 1. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/etx-19477-breast-ovarian-cancer-familial-susceptibility-to-1
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