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Gamma4 Heavy Chain Homo Sapiens (1-446) [Vh (Homo Sapiens Ighv4-39*01 (96.0%) -(Ighd) -Ighj3*02 (100%), Cdr-Imgt [10.7.12] (26-35.53-59.98-109)) (1-120)-Homo Sapiens Ighg4*01, Ng4M(A) Ch2 L92, G4V5 H P10, G4V4 Ch2 A1.3, A1.2 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 F1.3>A (234), L1.2>A (235), L92 (309) (231-340), Ch3 (341-445), Chs K2>Del (446)) (121-446)], (134-215')-Disulfide With Kappa Light Chain Homo Sapiens (1'-215') [V-Kappa (Homo Sapiens Igkv1-33*01 (96.8%) -Igkj4*01 (100%), Cdr-Imgt[6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo Sapiens Igkc*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')], Dimer (226-226'':229-229'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho)-K1Sv Cell Line Lacking The Glutamine Synthetase Gene (Gs-Ko), Glycoform Alfa

Cutaneous Melanoma

Explore 142 assets in Cutaneous Melanoma →
Floatz Rating
CCC48/100
Confidence
Indicative
v0.2
Sponsor
Innovent Biologics (Suzhou) Co. Ltd.
Modality
monoclonal_antibody
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Moderate confidence
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
NCT05572463CT.gov
A Platform Study of Novel Immunotherapy Products in Participants With Previously Treated Unresectable or Metastatic Cutaneous Melanoma
—Withdrawn———

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · Cutaneous Melanoma

AssetSponsorPhaseRating
Gamma4 Heavy Chain Homo Sapiens (1-446) [Vh (Homo Sapiens Ighv4-39*01 (96.0%) -(Ighd) -Ighj3*02 (100%), Cdr-Imgt [10.7.12] (26-35.53-59.98-109)) (1-120)-Homo Sapiens Ighg4*01, Ng4M(A) Ch2 L92, G4V5 H P10, G4V4 Ch2 A1.3, A1.2 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 F1.3>A (234), L1.2>A (235), L92 (309) (231-340), Ch3 (341-445), Chs K2>Del (446)) (121-446)], (134-215')-Disulfide With Kappa Light Chain Homo Sapiens (1'-215') [V-Kappa (Homo Sapiens Igkv1-33*01 (96.8%) -Igkj4*01 (100%), Cdr-Imgt[6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo Sapiens Igkc*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')], Dimer (226-226'':229-229'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho)-K1Sv Cell Line Lacking The Glutamine Synthetase Gene (Gs-Ko), Glycoform Alfa (this asset)Innovent Biologics (Suzhou) Co. Ltd.P1/2CCC · 48
Alpha-InterferonMIPO ClinicP3BBB
TILCity of Hope Medical CenterP2BBB
DacarbazineLinnaeus Therapeutics, Inc.P3BBB
Cis-Diamminedichloroplatinum IiMIPO ClinicP3BBB
Tyrosinase PeptideUniversity of Southern CaliforniaP3BBB
NivestimVastra Gotaland RegionP3BB
Multi-Epitope Melanoma Peptide VaccineCraig L Slingluff, JrP2BB
IfaCraig L Slingluff, JrP2BB

+42 more in the Cutaneous Melanoma cohort

Other indications for Gamma4 Heavy Chain Homo Sapiens (1-446) [Vh (Homo Sapiens Ighv4-39*01 (96.0%) -(Ighd) -Ighj3*02 (100%), Cdr-Imgt [10.7.12] (26-35.53-59.98-109)) (1-120)-Homo Sapiens Ighg4*01, Ng4M(A) Ch2 L92, G4V5 H P10, G4V4 Ch2 A1.3, A1.2 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 F1.3>A (234), L1.2>A (235), L92 (309) (231-340), Ch3 (341-445), Chs K2>Del (446)) (121-446)], (134-215')-Disulfide With Kappa Light Chain Homo Sapiens (1'-215') [V-Kappa (Homo Sapiens Igkv1-33*01 (96.8%) -Igkj4*01 (100%), Cdr-Imgt[6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo Sapiens Igkc*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')], Dimer (226-226'':229-229'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho)-K1Sv Cell Line Lacking The Glutamine Synthetase Gene (Gs-Ko), Glycoform Alfa

IndicationSponsorPhaseRating
Small Cell Lung Carcinoma—P1CC · 44
Diffuse Large B-Cell Lymphoma—P1CC · 43
Non-Small Cell Lung Carcinoma—P1C · 39

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. Gamma4 Heavy Chain Homo Sapiens (1-446) [Vh (Homo Sapiens Ighv4-39*01 (96.0%) -(Ighd) -Ighj3*02 (100%), Cdr-Imgt [10.7.12] (26-35.53-59.98-109)) (1-120)-Homo Sapiens Ighg4*01, Ng4M(A) Ch2 L92, G4V5 H P10, G4V4 Ch2 A1.3, A1.2 (Ch1 (121-218), Hinge 1-12 S10>P (228) (219-230), Ch2 F1.3>A (234), L1.2>A (235), L92 (309) (231-340), Ch3 (341-445), Chs K2>Del (446)) (121-446)], (134-215')-Disulfide With Kappa Light Chain Homo Sapiens (1'-215') [V-Kappa (Homo Sapiens Igkv1-33*01 (96.8%) -Igkj4*01 (100%), Cdr-Imgt[6.3.10] (27'-32'.50'-52'.89'-98')) (1'-108') -Homo Sapiens Igkc*01 (100%), Km3 A45.1 (154'), V101 (192') (109'-215')], Dimer (226-226'':229-229'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho)-K1Sv Cell Line Lacking The Glutamine Synthetase Gene (Gs-Ko), Glycoform Alfa in Cutaneous Melanoma. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/gamma4-heavy-chain-homo-sapiens-1-446-vh-homo-sapiens-ighv4-3901-960-ighd-ighj302-100-cdr-imgt-10712-26-3553-5998-109-1-120-homo-sapiens-ighg401-ng4ma-ch2-l92-g4v5-h-p10-g4v4-ch2-a13-a12-ch1-121-218-hinge-1-12-s10p-228-219-230-ch2-f13a-234-l12a-235-l92-309-231-340-ch3-341-445-chs-k2del-446-121-446-134-215-disulfide-with-kappa-light-chain-homo-sapiens-1-215-v-kappa-homo-sapiens-igkv1-3301-968-igkj401-100-cdr-imgt6310-27-3250-5289-98-1-108-homo-sapiens-igkc01-100-km3-a451-154-v101-192-109-215-dimer-226-226229-229-bisdisulfide-produced-in-chinese-hamster-ovary-cho-k1sv-cell-line-lacking-the-glutamine-synthetase-gene-gs-ko-glycoform-alfa-cutaneous-melanoma

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