Genetically-Modified Oncolytic Type 5 Adenovirus Which Selectively Replicates In Tumor Cells Containing Dysfunctional P53 Gene (H101)
Rectal Neoplasm
Explore 15 assets in Rectal Neoplasm →Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
Chongqing University Cancer Hospital
Modality
gene_therapy
Development Phase
Phase 2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT07543848CT.gov A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Rectal Neoplasm
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Genetically-Modified Oncolytic Type 5 Adenovirus Which Selectively Replicates In Tumor Cells Containing Dysfunctional P53 Gene (H101) (this asset) | Chongqing University Cancer Hospital | P2 | CCC · 53 |
| Ertapenem | University of Ulm | P4 | BB |
| Propofol | Uppsala University | P4 | BB |
| Oxaliplatin | Chongqing University Cancer Hospital | P3 | BB |
| Fluorouracilum | Pei-Rong Ding | P3 | BB |
| Sevoflurane | Uppsala University | P4 | BB |
| Capecitabine | Chongqing University Cancer Hospital | P3 | BB |
| Dilaudid | University of Illinois College of Medicine at Peoria | P4 | BB |
| Lidocaine | University of Illinois College of Medicine at Peoria | P4 | BB |
+36 more in the Rectal Neoplasm cohort
Other indications for Genetically-Modified Oncolytic Type 5 Adenovirus Which Selectively Replicates In Tumor Cells Containing Dysfunctional P53 Gene (H101)
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Hepatocellular Carcinoma | — | P3 | B · 56 |
| Female Reproductive System Neoplasm | — | P2 | CCC · 53 |
| Colorectal Cancer | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Genetically-Modified Oncolytic Type 5 Adenovirus Which Selectively Replicates In Tumor Cells Containing Dysfunctional P53 Gene (H101) in Rectal Neoplasm. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/genetically-modified-oncolytic-type-5-adenovirus-which-selectively-replicates-in-tumor-cells-containing-dysfunctional-p53-gene-h101-rectal-neoplasm
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