Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Modality
Small molecule
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06634108CT.gov Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy | — | Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Amyloidosis
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Genistein (this asset) | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | P1/2 | CCC · 48 |
| Acoramidis | Bayer | P4 | BBB |
| Dexasone | Ascentage Pharma Group Inc. | P3 | BB |
| Empagliflozin | Columbia University | P4 | BB |
| Tafamidis | Pfizer | P4 | BB |
| Lenalidomide | Ascentage Pharma Group Inc. | P3 | BB |
| Cyclophosphamide | University of Alabama at Birmingham | P2 | BB |
| Enavogliflozin | Seoul St. Mary's Hospital | P4 | BB |
| Inotersen | Brigham and Women's Hospital | P3 | BB |
+26 more in the Amyloidosis cohort
Other indications for Genistein
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Prostate Adenocarcinoma | — | P2 | CCC · 54 |
| Pediatric Lymphoma | — | P2 | CCC · 53 |
| Ewing Sarcoma | — | P2 | CCC · 53 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Genistein in Amyloidosis. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/genistein-amyloidosis
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