Floatz Rating
CCC48/100
Confidence
Indicative
Sponsor
George Washington University
Modality
UNKNOWN
Development Phase
Phase 1/2
Status
Active
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
33Indicative
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT06792500CT.gov A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) | — | Not Yet Recruiting | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
95Moderate confidence
Detailed axis rationale is planned and will be published soon.
Same indication · MELAS Syndrome
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Glycerol Tributyrate (this asset) | George Washington University | P1/2 | CCC · 48 |
| Sonlicromanol | Khondrion BV | P3 | BB |
| Fluzone | Stanford University | P4 | BB |
| Idebenone | Michio Hirano | P2 | B |
| ARG | The Hospital for Sick Children | P2 | B |
| Zagociguat | Tisento Therapeutics | P2 | CCC |
| Tti-0102 | Thiogenesis Therapeutics, Inc. | P2 | CCC |
| Napazimone | Abliva AB | P1 | CCC |
| Dichloroacetate | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | P2 | CCC |
+2 more in the MELAS Syndrome cohort
Other indications for Glycerol Tributyrate
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Leber Plus Disease | — | P1/2 | NR |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
Citation
Floatz Terminal. Glycerol Tributyrate in MELAS Syndrome. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/glycerol-tributyrate-melas-syndrome
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