Floatz Rating
CCC53/100
Confidence
Indicative
Sponsor
National Cancer Institute (NCI)
Modality
Small molecule
Development Phase
Phase 2
Status
Dormant
Evidence ledger · v0.2
Clinical Evidence
Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
38Moderate confidence
Detailed axis rationale is planned and will be published soon.
| Trial | Phase | Status | N | Primary endpoint | Readout |
|---|---|---|---|---|---|
NCT03165721CT.gov A Phase II Trial of the DNA Methyl Transferase Inhibitor, Guadecitabine (SGI-110), in Children and Adults With Wild Type GIST,Pheochromocytoma and Paraganglioma Associated With Succinate Dehydrogenase Deficiency and HLRCC-associated Kidney Cancer | — | Terminated | — | — | — |
Competitive Position
Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
89High confidence
Detailed axis rationale is planned and will be published soon.
Same indication · Pheochromocytoma
| Asset | Sponsor | Phase | Rating |
|---|---|---|---|
| Guadecitabine (this asset) | National Cancer Institute (NCI) | P2 | CCC · 53 |
| Adriamycin | European Organisation for Research and Treatment of Cancer - EORTC | P3 | BB |
| Isocyclophosphamide | European Organisation for Research and Treatment of Cancer - EORTC | P3 | BB |
| Nivestim | European Organisation for Research and Treatment of Cancer - EORTC | P3 | BB |
| Cis-Diamminedichloroplatinum Ii | Ottawa Regional Cancer Centre | P2 | B |
| Fostamatinib Disodium | National Cancer Institute (NCI) | P2 | B |
| Tamoxifen | Ottawa Regional Cancer Centre | P2 | B |
| L-Cysteinamide, D-Phenylalanyl-L-Cysteinyl-L-Phenylalanyl-D-Tryptophyl-L-Lysyl-L-Threonyl-N-(2-Hydroxy-1-(Hydroxymethyl)Propyl)-, Cyclic (2->7)-Disulfide, (R-(R*,R*))- | Vanderbilt-Ingram Cancer Center | P2 | CCC |
| Edotreotide | Excel Diagnostics and Nuclear Oncology Center | P2 | CCC |
+13 more in the Pheochromocytoma cohort
Other indications for Guadecitabine
| Indication | Sponsor | Phase | Rating |
|---|---|---|---|
| Fallopian Tube Carcinoma | — | P2 | BB · 66 |
| Ovarian Carcinoma | — | P2 | BB · 66 |
| Primary Peritoneal Carcinoma | — | P2 | BB · 66 |
Scientific Foundation
Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR
Planned for methodology v0.2.
Development Feasibility
How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR
Planned for methodology v0.2.
Commercial Opportunity
Commercial prize: addressable population, unmet need, and the value case for the indication.
NR
Planned for methodology v0.2.
IP & Exclusivity
Exclusivity position, covering patent protection and freedom-to-operate runway.
NR
Planned for methodology v0.2.
Manufacturing & Supply
Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR
Planned for methodology v0.2.
Related assets
- AdriamycinEuropean Organisation for Research and Treatment of Cancer - EORTCBB
- IsocyclophosphamideEuropean Organisation for Research and Treatment of Cancer - EORTCBB
- NivestimEuropean Organisation for Research and Treatment of Cancer - EORTCBB
- Cis-Diamminedichloroplatinum IiOttawa Regional Cancer CentreB
- Fostamatinib DisodiumNational Cancer Institute (NCI)B
Citation
Floatz Terminal. Guadecitabine in Pheochromocytoma. Methodology v0.2. Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026. Accessed July 14, 2026. https://terminal.floatz.ai/assets/guadecitabine-pheochromocytoma
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