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H-Gamma1 Heavy Chain Humanized (1-449) [Vh (Homo Sapiens Ighv3-23*01 (81.6%) -(Ighd) -Ighj3*02 (91.7%) M123>T (114), Cdr-Imgt [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo Sapiens Ighg1*03V (100%) G1M3>G1M17, Ng1M1 Ch1 K120, Ch3 E12, M14 (Ch1 R120>K (216) (120-217), Hinge 1-15 (218-232), Ch2 (233-342), Ch3 E12 (358), M14 (360) (343-447), Chs (448-449)) (120-449)], (222-218')-Disulfide With L-Kappa Light Chain Humanized (1'-218') [Vkappa (Homo Sapiens Igkv1-33*01 (87.8%) -Igkj4*01 (100%), Cdr-Imgt [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo Sapiens Igkc*01 (100%) Km3 A45.1, V101 (C-Kappaa45.1 (157'), V101 (195')) (112'-218')]; Dimer (228-228'':231-231'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Cho-K1, Glycoform Alfa

Esophageal Cancer

Explore 131 assets in Esophageal Cancer →
Floatz Rating
C37/100
Confidence
Indicative
v0.2
Sponsor
Genentech, Inc.
Modality
monoclonal_antibody
Development Phase
Phase 1
Status
Active
Evidence ledger · v0.2

Clinical Evidence

Clinical track record: trial progression, reported outcomes, safety signals, and endpoint quality.
28Indicative
Detailed axis rationale is planned and will be published soon.
TrialPhaseStatusNPrimary endpointReadout
NCT05581004CT.gov
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors
—Recruiting———

Competitive Position

Competitive setting: how crowded the indication is, class-level failures, and timing against rivals.
65High confidence
Detailed axis rationale is planned and will be published soon.

Same indication · Esophageal Cancer

AssetSponsorPhaseRating
H-Gamma1 Heavy Chain Humanized (1-449) [Vh (Homo Sapiens Ighv3-23*01 (81.6%) -(Ighd) -Ighj3*02 (91.7%) M123>T (114), Cdr-Imgt [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo Sapiens Ighg1*03V (100%) G1M3>G1M17, Ng1M1 Ch1 K120, Ch3 E12, M14 (Ch1 R120>K (216) (120-217), Hinge 1-15 (218-232), Ch2 (233-342), Ch3 E12 (358), M14 (360) (343-447), Chs (448-449)) (120-449)], (222-218')-Disulfide With L-Kappa Light Chain Humanized (1'-218') [Vkappa (Homo Sapiens Igkv1-33*01 (87.8%) -Igkj4*01 (100%), Cdr-Imgt [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo Sapiens Igkc*01 (100%) Km3 A45.1, V101 (C-Kappaa45.1 (157'), V101 (195')) (112'-218')]; Dimer (228-228'':231-231'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Cho-K1, Glycoform Alfa (this asset)Genentech, Inc.P1C · 37
Tisotumab VedotinSeagen Inc.P2BB
FluorouracilumMerck Sharp & Dohme LLCP4BB
EpirubicinSutro Biopharma, Inc.P3B
PembrolizumabEssen BiotechP3B
CetirizineCiusss de L'Est de l'Île de MontréalP3B
DocetaxelLaekna LimitedP2B
CapecitabineShenyang Sunshine Pharmaceutical Co., LTD.P2B
CyclophosphamideSutro Biopharma, Inc.P3B

+42 more in the Esophageal Cancer cohort

Other indications for H-Gamma1 Heavy Chain Humanized (1-449) [Vh (Homo Sapiens Ighv3-23*01 (81.6%) -(Ighd) -Ighj3*02 (91.7%) M123>T (114), Cdr-Imgt [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo Sapiens Ighg1*03V (100%) G1M3>G1M17, Ng1M1 Ch1 K120, Ch3 E12, M14 (Ch1 R120>K (216) (120-217), Hinge 1-15 (218-232), Ch2 (233-342), Ch3 E12 (358), M14 (360) (343-447), Chs (448-449)) (120-449)], (222-218')-Disulfide With L-Kappa Light Chain Humanized (1'-218') [Vkappa (Homo Sapiens Igkv1-33*01 (87.8%) -Igkj4*01 (100%), Cdr-Imgt [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo Sapiens Igkc*01 (100%) Km3 A45.1, V101 (C-Kappaa45.1 (157'), V101 (195')) (112'-218')]; Dimer (228-228'':231-231'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Cho-K1, Glycoform Alfa

IndicationSponsorPhaseRating
Nonpapillary Renal Cell Carcinoma—P1CC · 43
Triple-Negative Breast Carcinoma—P1CC · 41
Head And Neck Squamous Cell Carcinoma—P1CC · 41

Scientific Foundation

Strength of the underlying biology: target validation, tractability, modality fit, and how related mechanisms have fared.
NR

Planned for methodology v0.2.

Development Feasibility

How realistically the program can be executed, drawing on modality precedent, enrollment dynamics, and sponsor delivery.
NR

Planned for methodology v0.2.

Commercial Opportunity

Commercial prize: addressable population, unmet need, and the value case for the indication.
NR

Planned for methodology v0.2.

IP & Exclusivity

Exclusivity position, covering patent protection and freedom-to-operate runway.
NR

Planned for methodology v0.2.

Manufacturing & Supply

Manufacturing and supply readiness, driven by modality process and scale-up risk.
NR

Planned for methodology v0.2.

Related assets

Citation

Floatz Terminal. H-Gamma1 Heavy Chain Humanized (1-449) [Vh (Homo Sapiens Ighv3-23*01 (81.6%) -(Ighd) -Ighj3*02 (91.7%) M123>T (114), Cdr-Imgt [8.7.13] (26-33.51-57.96-108)) (1-119) -Homo Sapiens Ighg1*03V (100%) G1M3>G1M17, Ng1M1 Ch1 K120, Ch3 E12, M14 (Ch1 R120>K (216) (120-217), Hinge 1-15 (218-232), Ch2 (233-342), Ch3 E12 (358), M14 (360) (343-447), Chs (448-449)) (120-449)], (222-218')-Disulfide With L-Kappa Light Chain Humanized (1'-218') [Vkappa (Homo Sapiens Igkv1-33*01 (87.8%) -Igkj4*01 (100%), Cdr-Imgt [6.3.13] (27'-32'.50'-52'.89'-101')) (1'-111')-Homo Sapiens Igkc*01 (100%) Km3 A45.1, V101 (C-Kappaa45.1 (157'), V101 (195')) (112'-218')]; Dimer (228-228'':231-231'')-Bisdisulfide, Produced In Chinese Hamster Ovary (Cho) Cells, Cell Line Cho-K1, Glycoform Alfa in Esophageal Cancer. Methodology v0.2.
Rated under v0.2 effective July 8, 2026. Last refreshed July 8, 2026.
Accessed July 14, 2026.
https://terminal.floatz.ai/assets/h-gamma1-heavy-chain-humanized-1-449-vh-homo-sapiens-ighv3-2301-816-ighd-ighj302-917-m123t-114-cdr-imgt-8713-26-3351-5796-108-1-119-homo-sapiens-ighg103v-100-g1m3g1m17-ng1m1-ch1-k120-ch3-e12-m14-ch1-r120k-216-120-217-hinge-1-15-218-232-ch2-233-342-ch3-e12-358-m14-360-343-447-chs-448-449-120-449-222-218-disulfide-with-l-kappa-light-chain-humanized-1-218-vkappa-homo-sapiens-igkv1-3301-878-igkj401-100-cdr-imgt-6313-27-3250-5289-101-1-111-homo-sapiens-igkc01-100-km3-a451-v101-c-kappaa451-157-v101-195-112-218-dimer-228-228231-231-bisdisulfide-produced-in-chinese-hamster-ovary-cho-cells-cell-line-cho-k1-glycoform-alfa-esophageal-cancer

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